Thrombocytopenia: Difference between revisions
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==Definition== | ==Definition== | ||
<150,000 platelets/µL | <150,000 platelets/µL | ||
==Transfusion Criteria== | ==Transfusion Criteria== | ||
#<50,000 & severe bleed or invasive procedure | |||
#<20,000 & fever, petechia, or infection | |||
<50,000 & severe bleed or invasive procedure | #<5,000-10,000 --> always | ||
##Usually ineffective in ITP (give only in severe bleed; best after IVIg) | |||
<20,000 & fever, petechia, or infection | ##DIC may worsen with platlet tranfusion | ||
##Likely contraindicated in TTP | |||
<5,000-10,000 --> | |||
==Causes== | ==Causes== | ||
# Decreased production | |||
##marrow infiltration, aplastic anemia, drugs (ETOH), viral infect | |||
# Increased destruction | |||
##ITP, TTP, HUS, DIC, drugs (heparin) | |||
# Increased loss | |||
##hemorrhage, hemodialysis | |||
# Splenic sequestration | |||
# Pseudothrombocytopenia (clumped) | |||
==Pediatrics== | ==Pediatrics== | ||
1 unit platelets per 5kg body weight will raise count by 50k | 1 unit platelets per 5kg body weight will raise count by 50k | ||
==Source == | ==Source == | ||
1/26/06 DONALDSON (addapted from Tintinalli's, Lampe, Charfan) | 1/26/06 DONALDSON (addapted from Tintinalli's, Lampe, Charfan) | ||
[[Category:Heme/Onc]] | [[Category:Heme/Onc]] | ||
Revision as of 13:26, 15 March 2011
Definition
<150,000 platelets/µL
Transfusion Criteria
- <50,000 & severe bleed or invasive procedure
- <20,000 & fever, petechia, or infection
- <5,000-10,000 --> always
- Usually ineffective in ITP (give only in severe bleed; best after IVIg)
- DIC may worsen with platlet tranfusion
- Likely contraindicated in TTP
Causes
- Decreased production
- marrow infiltration, aplastic anemia, drugs (ETOH), viral infect
- Increased destruction
- ITP, TTP, HUS, DIC, drugs (heparin)
- Increased loss
- hemorrhage, hemodialysis
- Splenic sequestration
- Pseudothrombocytopenia (clumped)
Pediatrics
1 unit platelets per 5kg body weight will raise count by 50k
Source
1/26/06 DONALDSON (addapted from Tintinalli's, Lampe, Charfan)