Template:Antibiotics Open Fracture: Difference between revisions
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*Add [[Gentamicin]] 300 mg (1-1.7mg/kg) IV to any of the Grade I regemins | *Add [[Gentamicin]] 300 mg (1-1.7mg/kg) IV to any of the Grade I regemins | ||
**Once daily dosing has been shown to be safe and effective | **Once daily dosing has been shown to be safe and effective | ||
*If concern for [[Clostridium]] (soil contamination, farm injuries) then consider single drug regimen of [[Pipericillin/Tazobactam]] 4.5g (80mg/kg) IV TID | *If concern for [[Clostridium]] (soil contamination, farm injuries) then consider single drug regimen of [[Pipericillin/Tazobactam]] 4.5g (80mg/kg) IV TID | ||
Revision as of 23:46, 29 September 2017
- NNT 12.5 to prevent early fracture site infection[1]
Grade I Fracture Options
- Cefazolin (Ancef) 2g IV TID
- Ciprofloxacin 400mg IV BID (avoid in pediatrics)
Grade II/III Fracture Options
- Add Gentamicin 300 mg (1-1.7mg/kg) IV to any of the Grade I regemins
- Once daily dosing has been shown to be safe and effective
- If concern for Clostridium (soil contamination, farm injuries) then consider single drug regimen of Pipericillin/Tazobactam 4.5g (80mg/kg) IV TID
- ↑ Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.