Cilostazol

Administration

• Type: Tab
• Dosage Forms: 50 mg, 100 mg
• Routes of Administration: Oral
• Common Trade Names: Pletal

Adult Dosing

Intermittent claudication

• 100 mg PO bid

Pediatric Dosing

Safety/efficacy not established in pediatric patients

Special Populations

Pregnancy Rating

• Caution advised during pregnancy
• No risk of fetal harm, teratogenicity, or death
• Increased risk of maternal bleeding during delivery

Lactation risk

• Caution advised while breastfeeding

Renal Dosing

• Adult: No adjustment
• Pediatric: Unavailable

Hepatic Dosing

• Adult: No adjustment
• Pediatric: Unavailable

Contraindications

• Allergy to class/drug
• CHF
• Hemostatic disorders
• Active bleeding

Adverse Reactions

Serious

• Bleeding
• Angina, MI
• Tachyarrhythmia
• Thrombocytopenia
• Leukopenia, Agranulocytosis
• Anaphylaxis
• Stevens-Johnson Syndrome

Common

• Headache
• Diarrhea, Abnormal stools, abdominal pain
• Palpitations, dizziness, tachycardia
• Peripheral edema
• Dyspepsia

Pharmacology

• Half-life: 11-13 hours; active metabolites
• Metabolism: Liver; CYP450: 2C19, 3A4
• Excretion: Urine 74%, feces 20%

Mechanism of Action

• Inhibits phosphodiesterase type 3, reducing platelet aggregation
• Suppresses cAMP degradation, producing vasodilation