Amyotrophic lateral sclerosis: Difference between revisions
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==Background== | ==Background== | ||
*Progressive muscle atrophy/weakness due to degeneration of upper and lower motor neurons | *Progressive muscle atrophy/weakness due to degeneration of upper and lower motor neurons | ||
* | *Patients will rarely present to the ED undiagnosed | ||
*Likely related to mutated superoxide dismutase (SOD1) gene | |||
==Clinical Features== | ==Clinical Features== | ||
| Line 20: | Line 21: | ||
==Source== | ==Source== | ||
Tintinalli | Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 7e (2010), Chapter 167. Chronic Neurologic Disorders | ||
[[Category:Neuro]] | [[Category:Neuro]] | ||
Revision as of 03:59, 26 March 2014
Background
- Progressive muscle atrophy/weakness due to degeneration of upper and lower motor neurons
- Patients will rarely present to the ED undiagnosed
- Likely related to mutated superoxide dismutase (SOD1) gene
Clinical Features
- Acute respiratory failure
- Predicted by forced VC <25 mL/kg or 50% decrease from normal
- Aspiration pneumonia
- Trauma related to extremity weakness
Management
- Nebulized medications
- Steroids
- Antibiotics
- Assisted ventilation / intubation
See Also
Source
Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 7e (2010), Chapter 167. Chronic Neurologic Disorders