Template:Antibiotics Open Fracture: Difference between revisions
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===Prophylactic Antibiotics for [[Open fractures]]=== | ===Prophylactic Antibiotics for [[Open fractures]]<ref>Open Fractures, Prophylactic Antibiotic Use in — Update. https://www.east.org/education/practice-management-guidelines/open-fractures-prophylactic-antibiotic-use-in-update</ref>=== | ||
''NNT 12.5 to prevent early fracture site infection<ref>Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.</ref>'' | ''NNT 12.5 to prevent early fracture site infection<ref>Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.</ref>'' | ||
====Grade I | ====Grade I & II Fractures Options==== | ||
*[[Cefazolin]] (Ancef) 2g IV TID | *[[Cefazolin]] (Ancef) 2g IV TID | ||
*[[Ciprofloxacin]] 400mg IV BID (avoid in pediatrics) | *[[Ciprofloxacin]] 400mg IV BID (avoid in pediatrics) | ||
====Grade | ====Grade III Fracture Options==== | ||
*Add [[Gentamicin]] 300 mg (1-1.7mg/kg) IV to any of the Grade I regemins | *Add [[Gentamicin]] 300 mg (1-1.7mg/kg) IV to any of the Grade I regemins | ||
**Once daily dosing has been shown to be safe and effective | **Once daily dosing has been shown to be safe and effective | ||
*If concern for [[Clostridium]] (soil contamination, farm injuries) then consider single drug regimen of [[Pipericillin/Tazobactam]] 4.5g (80mg/kg) IV TID | *If concern for [[Clostridium]] (soil contamination, farm injuries) then consider single drug regimen of [[Pipericillin/Tazobactam]] 4.5g (80mg/kg) IV TID | ||
Revision as of 04:53, 18 September 2018
Prophylactic Antibiotics for Open fractures[1]
NNT 12.5 to prevent early fracture site infection[2]
Grade I & II Fractures Options
- Cefazolin (Ancef) 2g IV TID
- Ciprofloxacin 400mg IV BID (avoid in pediatrics)
Grade III Fracture Options
- Add Gentamicin 300 mg (1-1.7mg/kg) IV to any of the Grade I regemins
- Once daily dosing has been shown to be safe and effective
- If concern for Clostridium (soil contamination, farm injuries) then consider single drug regimen of Pipericillin/Tazobactam 4.5g (80mg/kg) IV TID
- ↑ Open Fractures, Prophylactic Antibiotic Use in — Update. https://www.east.org/education/practice-management-guidelines/open-fractures-prophylactic-antibiotic-use-in-update
- ↑ Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.