Pralidoxime: Difference between revisions
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==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C | ||
*[[Lactation risk categories|Lactation risk]]: | *[[Lactation risk categories|Lactation risk]]: Unknown | ||
*Renal Dosing | *Renal Dosing | ||
**Adult | **Adult - no requirements from manufacturer, but given that it is excreted in the urine dosage reduction is recommended. | ||
**Pediatric | **Pediatric | ||
*Hepatic Dosing | *Hepatic Dosing | ||
**Adult | **Adult - no adjustments recommended by manufacturer. | ||
**Pediatric | **Pediatric | ||
Revision as of 19:03, 26 January 2019
General
- Type:
- Dosage Forms:
- Common Trade Names:
Adult Dosing
Organophosphate toxicity
- 1-2gm IV over 5-10min
- Continuous infusion of 500mg/hr if no initial response
Pediatric Dosing
Organophosphate toxicity
- 20-40mg/kg (up to 1gm) IV over 5-10min
- 5-10mg/kg/hr if no initial response
Special Populations
- Pregnancy Rating: C
- Lactation risk: Unknown
- Renal Dosing
- Adult - no requirements from manufacturer, but given that it is excreted in the urine dosage reduction is recommended.
- Pediatric
- Hepatic Dosing
- Adult - no adjustments recommended by manufacturer.
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Tachycardia
- Hypertension
- Laryngospasm
- Hepatitis
Common
Pharmacology
- Half-life: Apparent: 74 to 77 minutes, IM/IV exposure: 3 to 4 hours
- Metabolism: Hepatic
- Excretion: Urine
- Mechanism of Action: Displaces an organophosphate from acetylcholinesterase (if given early before irreversible enzyme binding occurs, aka "aging")