P450: Difference between revisions
No edit summary |
ClaireLewis (talk | contribs) No edit summary |
||
| (6 intermediate revisions by 3 users not shown) | |||
| Line 2: | Line 2: | ||
[[Coumadin]] | [[Coumadin]] | ||
===Avoid / P450 Inhibitors=== | ==Antimicrobials== | ||
*[[Quinolones]], | ===Avoid /[[P450]] Inhibitors=== | ||
*[[Macrolides]], | *[[Quinolones]], especially [[levofloxacin]] | ||
*[[Macrolides]], especially [[erythromycin]] | |||
*[[Bactrim]] and sulfonamides | *[[Bactrim]] and sulfonamides | ||
*[[Flagyl]] | *[[Flagyl]] | ||
| Line 11: | Line 12: | ||
===Use=== | ===Use=== | ||
*[[Azithromycin]] | *[[Azithromycin]] | ||
*[[Gentamicin | *[[Gentamicin]] | ||
*[[Cephalosporin]], [[aminopenicillins]] | *[[Cephalosporin]], [[aminopenicillins]] | ||
*[[Nitrofurantoin]] | *[[Nitrofurantoin]] | ||
| Line 17: | Line 18: | ||
*[[Vancomycin]] | *[[Vancomycin]] | ||
[[Category: | ==Significant [[P450]] Inhibitors in General== | ||
*Grapefruit juice | |||
*[[Valproate]]] | |||
*[[INH]] | |||
*Protease inhibitors (-navir, i.e. ritonavir) | |||
*[[SSRIs]], except escitalopram | |||
*[[Amiodarone]] | |||
*[[Fluoroquinolones]] | |||
*[[Sulfonamides]] | |||
*[[Macrolides]] | |||
*[[Cimetidine]] | |||
*[[Omeprazole]] | |||
*[[Ketoconazole]] | |||
*Acute [[ETOH]] | |||
==Significant [[P450]] Inducers in General== | |||
*[[Phenytoin]] | |||
*[[Carbamazepine]] | |||
*[[Ethosuximide]] | |||
*[[Quinidine]]/[[quinine]] | |||
*[[Rifampin]] | |||
*[[Griseofulvin]] | |||
*[[Glucocorticoids]] | |||
*[[Barbiturates]] | |||
*St. John's wort | |||
*Chronic EtOH | |||
*[[Tobacco]] smoking | |||
[[Category:Pharmacology]] | |||
Latest revision as of 01:28, 27 January 2019
Background
Antimicrobials
Avoid /P450 Inhibitors
- Quinolones, especially levofloxacin
- Macrolides, especially erythromycin
- Bactrim and sulfonamides
- Flagyl
- Nafcillin, oxacillin
Use
Significant P450 Inhibitors in General
- Grapefruit juice
- Valproate]
- INH
- Protease inhibitors (-navir, i.e. ritonavir)
- SSRIs, except escitalopram
- Amiodarone
- Fluoroquinolones
- Sulfonamides
- Macrolides
- Cimetidine
- Omeprazole
- Ketoconazole
- Acute ETOH
Significant P450 Inducers in General
- Phenytoin
- Carbamazepine
- Ethosuximide
- Quinidine/quinine
- Rifampin
- Griseofulvin
- Glucocorticoids
- Barbiturates
- St. John's wort
- Chronic EtOH
- Tobacco smoking