P450: Difference between revisions
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==Antimicrobials== | ==Antimicrobials== | ||
===Avoid / P450 Inhibitors=== | ===Avoid /[[P450]] Inhibitors=== | ||
*[[Quinolones]], | *[[Quinolones]], especially [[levofloxacin]] | ||
*[[Macrolides]], | *[[Macrolides]], especially [[erythromycin]] | ||
*[[Bactrim]] and sulfonamides | *[[Bactrim]] and sulfonamides | ||
*[[Flagyl]] | *[[Flagyl]] | ||
| Line 12: | Line 12: | ||
===Use=== | ===Use=== | ||
*[[Azithromycin]] | *[[Azithromycin]] | ||
*[[Gentamicin | *[[Gentamicin]] | ||
*[[Cephalosporin]], [[aminopenicillins]] | *[[Cephalosporin]], [[aminopenicillins]] | ||
*[[Nitrofurantoin]] | *[[Nitrofurantoin]] | ||
| Line 18: | Line 18: | ||
*[[Vancomycin]] | *[[Vancomycin]] | ||
==Significant P450 Inhibitors in General== | ==Significant [[P450]] Inhibitors in General== | ||
*Grapefruit juice | *Grapefruit juice | ||
*Valproate | *[[Valproate]]] | ||
*INH | *[[INH]] | ||
*Protease inhibitors (-navir, i.e. ritonavir) | *Protease inhibitors (-navir, i.e. ritonavir) | ||
*SSRIs, except escitalopram | *[[SSRIs]], except escitalopram | ||
*[[Amiodarone]] | *[[Amiodarone]] | ||
*Fluoroquinolones | *[[Fluoroquinolones]] | ||
*Sulfonamides | *[[Sulfonamides]] | ||
*Macrolides | *[[Macrolides]] | ||
*Cimetidine | *[[Cimetidine]] | ||
*Omeprazole | *[[Omeprazole]] | ||
*Ketoconazole | *[[Ketoconazole]] | ||
*Acute | *Acute [[ETOH]] | ||
==Significant P450 Inducers in General== | ==Significant [[P450]] Inducers in General== | ||
*Phenytoin | *[[Phenytoin]] | ||
*Carbamazepine | *[[Carbamazepine]] | ||
*Ethosuximide | *[[Ethosuximide]] | ||
*Quinidine/quinine | *[[Quinidine]]/[[quinine]] | ||
*Rifampin | *[[Rifampin]] | ||
*Griseofulvin | *[[Griseofulvin]] | ||
*Glucocorticoids | *[[Glucocorticoids]] | ||
* | *[[Barbiturates]] | ||
*St. John's wort | *St. John's wort | ||
*Chronic EtOH | *Chronic EtOH | ||
*Tobacco smoking | *[[Tobacco]] smoking | ||
[[Category: | [[Category:Pharmacology]] | ||
Latest revision as of 01:28, 27 January 2019
Background
Antimicrobials
Avoid /P450 Inhibitors
- Quinolones, especially levofloxacin
- Macrolides, especially erythromycin
- Bactrim and sulfonamides
- Flagyl
- Nafcillin, oxacillin
Use
Significant P450 Inhibitors in General
- Grapefruit juice
- Valproate]
- INH
- Protease inhibitors (-navir, i.e. ritonavir)
- SSRIs, except escitalopram
- Amiodarone
- Fluoroquinolones
- Sulfonamides
- Macrolides
- Cimetidine
- Omeprazole
- Ketoconazole
- Acute ETOH
Significant P450 Inducers in General
- Phenytoin
- Carbamazepine
- Ethosuximide
- Quinidine/quinine
- Rifampin
- Griseofulvin
- Glucocorticoids
- Barbiturates
- St. John's wort
- Chronic EtOH
- Tobacco smoking