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| *[[Thrombolytics for STEMI]] | | *[[Thrombolytics for STEMI]] |
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| ==Thrombolysis contraindications== | | ==Medications== |
| ===Absolute contraindication===
| | *[[Alteplase]] (TPA) |
| *Any prior ICH
| | *[[Tenecteplase]] (TNKase) |
| *Known structural cerebral vascular lesion (AVM)
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| *Known intracranial neoplasm
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| *Ischemic stroke within 3 mo
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| *Active internal bleeding (excluding menses)
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| *Suspected aortic dissection or pericarditis
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| ===Relative contraindications===
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| *Severe uncontrolled BP (>180/110)
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| *History of chronic severe poorly controlled hypertension | |
| *History of ischemic stroke within past 3 months
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| *Known intracranial pathology not covered in absolute contraindications
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| *Current use of anticoagulants with known INR >2–3
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| *Known bleeding diathesis
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| *Recent trauma (past 2 wk)
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| *Prolonged CPR (>10 min)
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| *Major surgery (<3 wk) | |
| *Noncompressible vascular punctures (e.g. subclavian) within past 7 days
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| *Recent internal bleeding (within 2–4 wk)
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| *Patients treated previously with streptokinase should not receive streptokinase again
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| *Pregnancy
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| *Active peptic ulcer disease
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| *Other medical conditions likely to increase risk of bleeding (diabetic retinopathy, etc)
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| ==See Also== | | ==See Also== |
| *[[Ischemic stroke]]
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| *[[STEMI]]
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| ==References== | | ==References== |
