Dopamine: Difference between revisions
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==Pharmacology== | ==Pharmacology<ref>Dopamine: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. </ref>== | ||
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Revision as of 04:33, 2 May 2019
General
- Type: Vasopressors
- Dosage Forms: IV
- Common Trade Names: Intropin
Adult Dosing
Dosing
- Low dose:
- 1-5 mcg/kg/min - Vasodilation (renal, mesenteric, coronary)
- 5-10 mcg/kg/min - predominant β1
- High dose: 10-20 mcg/kg/min - predominant α1
- Titrate to clinical effect
- Use lowest dose possible (prevent tachyphylaxis)
- May use in peripheral IV temporarily
- Avoid using in same line as alkaline infusions
Rate of Titration
- Q2-5 min
Pediatric Dosing
Special Populations
- Pregnancy Rating: Class C
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
- Tachyarrhythmias
Adverse Reactions
- Low doses:
- Hypotension
- High doses:
- Hypertension, ectopic beats
- Tissue necrosis (if extravasates)
- If occurs use phentolamine 5-10mg in affected area
Serious
Common
Pharmacology[1]
- Half-life:
- 2 minutes
- Metabolism:
- Renal, Hepatic, Plasma
- Excretion:
- Urine as metabolites
- Mechanism of Action:
Primary Receptor
- Low dose: DA, β1
- High dose: DA, α1 >> β1
Relative Effects
- Low dose: Natriuresis, ↑↑HR, ↑↑SV
- High dose: ↑SVR and ↑SV
Notes
Indications
- Hypotensioncaused by:
- Septic shock
- MI
- Trauma/spinal shock
- Heart failure
See Also
References
- ↑ Dopamine: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.