Trazodone toxicity: Difference between revisions
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==Management== | ==Management== | ||
* | *Supportive care | ||
*[[Activated charcoal]] and [[gastric lavage]] are not indicated | |||
*[[QT prolongation]] | *[[QT prolongation]] | ||
**Treat [[torsades]] in usual manner | **Treat [[torsades]] in usual manner | ||
Revision as of 14:40, 1 September 2019
Background
- Trazodone is extremely safe in overdose as long as there are no coingestants
- Has serotonergic and α blocking effects
Clinical Features
- CNS depression
- Most common symptom
- Rarely produces coma or seizures when it is the only drug ingested
- Respiratory depresion
- Fairly common (but only with coingestants)
- Orthostatic hypotension
- QT prolongation
Differential Diagnosis
Evaluation
Management
- Supportive care
- Activated charcoal and gastric lavage are not indicated
- QT prolongation
- Treat torsades in usual manner
- Hypotension
- IVF
- Norepinephrine
- Dopamine is contraindicated
Disposition
- Consider discharge for patients who remain asymptomatic for at least 6 hours