Etomidate: Difference between revisions
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''See [[critical care quick reference]] for drug doses by weight.'' | ''See [[critical care quick reference]] for drug doses by weight.'' | ||
==General== | ==General== | ||
*Type: | *Type: [[Sedation|Sedative]] | ||
*Dosage Forms: | *Dosage Forms: | ||
*Common Trade Names: | *Common Trade Names: | ||
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==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C | ||
*Lactation: etomidate is present in breast milk | *Lactation: etomidate is present in breast milk | ||
*Renal Dosing | *Renal Dosing | ||
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[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:Critical Care]] | |||
Etomidate: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. | Etomidate: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. | ||
Revision as of 19:38, 22 September 2019
See critical care quick reference for drug doses by weight.
General
- Type: Sedative
- Dosage Forms:
- Common Trade Names:
Adult Dosing
RSI
- 0.3mg/kg bolus IV
- Standard dose = 20mg
Procedural Sedation
- 0.1mg/kg one time dosing
- Max: 10mg
- Minimal respiratory depression but decrease blood pressure and heart rate (alpha2 agonism)
Pediatric Dosing
See critical care quick reference for drug doses by weight.
RSI
- 0.3mg/kg bolus IV
- Max: 20mg
Procedural Sedation
- 0.1mg/kg one time dosing
- Max: 10mg
- Minimal respiratory depression but decrease blood pressure and heart rate (alpha2 agonism)
Special Populations
- Pregnancy Rating: C
- Lactation: etomidate is present in breast milk
- Renal Dosing
- Adult
- Not defined however higher risk of toxicity with renal impairment
- Pediatric
- Not defined however higher risk of toxicity with renal impairment
- Adult
- Hepatic Dosing
- Adult
- Not defined
- Pediatric
- Not defined
- Adult
Contraindications
- Allergy to class/drug
Adverse Reactions
- Myoclonus
- Nausea/Vomiting
- Pain at injection site
- apnea
Controversy
"The available evidence suggests that etomidate suppresses adrenal function transiently without demonstrating a significant effect on mortality. However, no studies to date have been powered to detect a difference in hospital, ventilator, or ICU length of stay or in mortality."[1]
Pharmacology
- Half-life: 75 minutes
- Metabolism: Liver
- Excretion: Urine
- Mechanism of Action: GABA agonist
See Also
References
- ↑ *Hohl CM, Kelly-Smith CH,Yeung TC, Sweet DD, Doyle-Waters MM, Schulzer M. The effect of a bolus dose of Etomidate on cortisol levels, mortality, and health services utilization: a systematic review. Ann Emerg Med. 2010;56(2):105-113.
Etomidate: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.