Nitroglycerin: Difference between revisions
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==General== | ==General== | ||
*Type: stimulates cGMP production causing vascular smooth muscle relaxation | *Type: vasodilator; stimulates cGMP production causing vascular smooth muscle relaxation | ||
*Dosage Forms: SL, IV | *Dosage Forms: SL, IV | ||
*Common Trade Names: Nitrolingual, NitroMist, Nitrostat | *Common Trade Names: Nitrolingual, NitroMist, Nitrostat | ||
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==Pharmacology== | ==Pharmacology== | ||
*Half-life: 1-3 min | *Half-life: 1-3 min | ||
*Metabolism: liver, | *Metabolism: liver, erythrocytes, vascular walls | ||
*Excretion: urine | *Excretion: urine | ||
*Mechanism of Action: stimulates cGMP production resulting in vascular smooth muscle relaxation | *Mechanism of Action: stimulates cGMP production resulting in vascular smooth muscle relaxation | ||
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[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:Cardiology]] | |||
Revision as of 23:56, 22 September 2019
General
- Type: vasodilator; stimulates cGMP production causing vascular smooth muscle relaxation
- Dosage Forms: SL, IV
- Common Trade Names: Nitrolingual, NitroMist, Nitrostat
Adult Dosing
- Angina, Acute: 0.3 - 0.6mg SL q5min x 3 doses max
- hypertension/CHF: 5-200 mcg/min IV, start 5 mcg/min IV
Pediatric Dosing
hypertension/CHF: 1-5 mcg/kg/min IV, start 0.25-0.5 mcg/kg/min, max: 20 mcg/kg/min
Special Populations
- Pregnancy Rating: C
- Lactation: safety unknown
- Renal Dosing
- Adult: no adjustment
- Pediatric: no adjustment
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- Pericardial tamponade
- severe anemia
- sildenafil use
- methemoglobinemia
- caution if hypotension
Adverse Reactions
Serious
- hypotension
- bradycardia
- methemoglobinemia
Common
- headache
- dizziness
- flushing
- hypotension
- reflex tachycardia
- edema
Pharmacology
- Half-life: 1-3 min
- Metabolism: liver, erythrocytes, vascular walls
- Excretion: urine
- Mechanism of Action: stimulates cGMP production resulting in vascular smooth muscle relaxation