Nitroglycerin: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===Angina, acute=== | |||
* | *0.3 - 0.6mg SL q5min, max: 3 doses within 15 min | ||
*IV form: 5 mcg/min IV, increase 5-20 mcg/min q3-5min. | |||
===[[Hypertension]]=== | |||
*5-200 mcg/min IV, start 5 mcg/min IV and increase increase 5 mcg/min q3-5min | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===[[Hypertension]]/[[CHF]]=== | |||
*1-5 mcg/kg/min IV, start 0.25-0.5 mcg/kg/min, max: 20 mcg/kg/min | |||
==Special Populations== | ==Special Populations== | ||
Revision as of 23:59, 22 September 2019
General
- Type: vasodilator; stimulates cGMP production causing vascular smooth muscle relaxation
- Dosage Forms: SL, IV
- Common Trade Names: Nitrolingual, NitroMist, Nitrostat
Adult Dosing
Angina, acute
- 0.3 - 0.6mg SL q5min, max: 3 doses within 15 min
- IV form: 5 mcg/min IV, increase 5-20 mcg/min q3-5min.
Hypertension
- 5-200 mcg/min IV, start 5 mcg/min IV and increase increase 5 mcg/min q3-5min
Pediatric Dosing
Hypertension/CHF
- 1-5 mcg/kg/min IV, start 0.25-0.5 mcg/kg/min, max: 20 mcg/kg/min
Special Populations
- Pregnancy Rating: C
- Lactation: safety unknown
- Renal Dosing
- Adult: no adjustment
- Pediatric: no adjustment
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- Pericardial tamponade
- severe anemia
- sildenafil use
- methemoglobinemia
- caution if hypotension
Adverse Reactions
Serious
- hypotension
- bradycardia
- methemoglobinemia
Common
- headache
- dizziness
- flushing
- hypotension
- reflex tachycardia
- edema
Pharmacology
- Half-life: 1-3 min
- Metabolism: liver, erythrocytes, vascular walls
- Excretion: urine
- Mechanism of Action: stimulates cGMP production resulting in vascular smooth muscle relaxation