Hydrocodone/Acetaminophen

General

• Type: opioid (hydrocodone) + acetaminophen
• Dosage Forms: PO
• Common Trade Names: Norco

Adult Dosing

General

Pain:

• 2.5-10mg hydrocodone/325mg Acetaminophen PO q4-6h

Pediatric Dosing

Not Currently recommended

Special Populations

• Pregnancy Rating: C
• Lactation Risk Categories: possibly unsafe
• Renal Dosing
  • Adult: none
  • Pediatric: none
• Hepatic Dosing
  • Adult: not defined
  • Pediatric: not defined

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Respiratory Depression
• Apnea
• syncope
• bradycardia
• Seizures
• anaphylaxis
• acetaminophen toxicity

Common

• Nausea
• Rash
• Headache
• Fatigue
• xerostomia
• constipation
• Tremor
• transaminitis

Pharmacology

• Half-life: 4-5 hour
• Metabolism: Liver
• Excretion: urine
• Mechanism of Action:binds to various opioid receptors