Sodium phenylacetate/sodium benzoate

Administration

• Type:
• Dosage Forms:
• Routes of Administration: IV
• Common Trade Names: Ammunol

Adult Dosing

• 5.5g/m2 over 90-120min

Pediatric Dosing

Hyperammonemia

• <20kg: 250mg/kg in D10 over 90min; then 250mg/kg/d infusion
• >20kg: 5.5g/m2 over 90-120min

Special Populations

Pregnancy Rating

• Pregnancy Category C

Lactation risk

• Unknown risk

Renal Dosing

• Adult: Monitor closely
• Pediatric: Monitor closely

Hepatic Dosing

• Adult: caution with use
• Pediatric: caution with use

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Hypokalemia
• Fluid overload
• Tissue damage with extravasation from peripheral IV
• Neurotoxicity, seizure, coma
• Hyperventilation with metabolic acidosis (similar to salicylate toxicity)

Common

• Vomiting, hyperglycemia, hypokalemia, convulsions, and mental impairment.

Pharmacology

• Half-life:
• Metabolism:
• Excretion:

See Also

• Inborn errors of metabolism