Chondrosarcoma: Difference between revisions
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==Evaluation== | ==Evaluation== | ||
*Plain radiographs reveal punctate calcifications and cortical bone destruction | |||
*CT or MRI to assess extent of bone involvement | |||
*Bone biopsy for definitive diagnosis | |||
==Management== | ==Management== | ||
Revision as of 22:27, 21 November 2019
Background
- Third most common primary bone malignancy after multiple myeloma and osteosarcoma
- Around ninety percent of chondrosarcomas are of low metastatic potential
- Osteochondromas and enchondromas can be precursors lesions
Pathophysiology
- Overproduction of chondroid matrix in the medullary cavity
Clinical Features
- Lesions commonly in the pelvis and central skeleton
- Occurs in patients over 40 years-old with a male predominance
- Often will present with local swelling and pain or a pathologic fracture
- Very slow growing tumors
Differential Diagnosis
Malignant
- Multiple myeloma
- Osteosarcoma
- Paget disease
- Ewing sarcoma
- Giant cell tumor
- Adamantinoma
- Chordoma
- Primary bone lymphoma
- Fibrosarcoma
- Myosarcoma
Benign
- Chrondroblastoma
- Enchondroma
- Langerhans cell histiocytosis of bone
- Osteoblastoma
- Osteochondroma
- Osteoid Osteoma
Evaluation
- Plain radiographs reveal punctate calcifications and cortical bone destruction
- CT or MRI to assess extent of bone involvement
- Bone biopsy for definitive diagnosis