25C-NBOMe: Difference between revisions
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*Other names: NBOMe-2C-C, Boom, C-Boom, Cimbi-82, Pandora, N-bomb, Holland film, Dime | *Other names: NBOMe-2C-C, Boom, C-Boom, Cimbi-82, Pandora, N-bomb, Holland film, Dime | ||
*Potent partial agonist of 5-HT2A receptor | *Potent partial agonist of 5-HT2A receptor | ||
*Member of new class of toxic phenethylamine derivatives (NBOMe) | *Member of new class of toxic phenethylamine derivatives (NBOMe) with similar effects to [[LSD]] | ||
*Commonly ingested orally or sublingually; can also be ingested nasally, parenterally, vaginally, rectally | *Commonly ingested orally or sublingually; can also be ingested nasally, parenterally, vaginally, rectally | ||
*Dose of 50-200 micrograms causes hallucinogenic effects | *Dose of 50-200 micrograms causes hallucinogenic effects | ||
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*Visual/Auditory hallucinations | *Visual/Auditory hallucinations | ||
*Stimulation +/- tremors, bruxism | *Stimulation +/- tremors, bruxism | ||
*Serotonin | *[[Serotonin Syndrome]] ([[AMS]], [[Hyperthermia]], rigidity, autonomic instability) | ||
*Confusion | *Confusion | ||
*Agitation | *Agitation | ||
*Vasoconstriction | *Vasoconstriction | ||
*Nausea | *[[Nausea and Vomiting]] | ||
*Headache | *[[Headache]] | ||
*Palpitations | *Palpitations | ||
*Diaphoresis | *Diaphoresis | ||
*Dysuria | *[[Dysuria]] | ||
*Hypertension | *Hypertension | ||
*Generalized | *Generalized [[Seizure]] | ||
*Mydriasis | *Mydriasis | ||
*Acute | *[[Acute Renal Failure]] | ||
*Metabolic | *[[Metabolic Acidosis]] | ||
==Workup== | ==Workup== | ||
*ISTAT | *ISTAT | ||
*Urine pregnancy | *Urine pregnancy | ||
*CBC, BMP, LFTs, coags, APAP, ASA | *CBC, BMP, LFTs, coags, [[Acetaminophen (Tylenol) Toxicity|APAP level]], [[Aspirin Toxicity|ASA level]] | ||
*CK | *[[Rhabdomyolysis|Total CK level]] | ||
*ECG | *[[ECG_(Basics)|ECG]] | ||
*UA | *UA | ||
*Tox screen, blood alcohol | *Tox screen, blood alcohol | ||
*Serum osmoles, urine Na (if | *Serum osmoles, urine Na (if [[Hyponatremia]] present) | ||
*Head CT as indicated | *Head CT as indicated | ||
*LP | *LP to rule out [[Meningitis]] if infectious symptoms and based on history and physical | ||
==Treatment== | ==Treatment== | ||
*ABCs | *ABCs | ||
*IV, O2, monitor | *IV, O2, monitor | ||
*Agitation | *'''Agitation''' | ||
** | **[[Benzodiazepines]] | ||
** | **[[Haldol]] for acute agitation | ||
*Seizure | *'''[[Seizure]]''' | ||
** | **[[Benzodiazepines]] | ||
**manage airway as indicated | **manage airway as indicated | ||
*Hyperthermia: | *[[Hyperthermia]]: | ||
**ice packs, cold IVF | **ice packs, cold IVF | ||
==Disposition== | ==Disposition== | ||
*Admit pt's with complications of ingestion | *Admit pt's with complications of ingestion | ||
==See Also== | |||
*[[LSD]] | |||
*[[Ecstasy (MDMA)]] | |||
*[[Hallucinations]] | |||
*[[Hallucinogens]] | |||
==Sources== | ==Sources== | ||
Revision as of 03:55, 9 November 2014
Background
- 2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
- Other names: NBOMe-2C-C, Boom, C-Boom, Cimbi-82, Pandora, N-bomb, Holland film, Dime
- Potent partial agonist of 5-HT2A receptor
- Member of new class of toxic phenethylamine derivatives (NBOMe) with similar effects to LSD
- Commonly ingested orally or sublingually; can also be ingested nasally, parenterally, vaginally, rectally
- Dose of 50-200 micrograms causes hallucinogenic effects
- Onset 0-15 mins, peak 30-90 mins, total duration 4-10 hours
Clinical Features
- Metallic chemical taste
- Sense of numbness of tongue and mouth
- Euphoria
- Visual/Auditory hallucinations
- Stimulation +/- tremors, bruxism
- Serotonin Syndrome (AMS, Hyperthermia, rigidity, autonomic instability)
- Confusion
- Agitation
- Vasoconstriction
- Nausea and Vomiting
- Headache
- Palpitations
- Diaphoresis
- Dysuria
- Hypertension
- Generalized Seizure
- Mydriasis
- Acute Renal Failure
- Metabolic Acidosis
Workup
- ISTAT
- Urine pregnancy
- CBC, BMP, LFTs, coags, APAP level, ASA level
- Total CK level
- ECG
- UA
- Tox screen, blood alcohol
- Serum osmoles, urine Na (if Hyponatremia present)
- Head CT as indicated
- LP to rule out Meningitis if infectious symptoms and based on history and physical
Treatment
- ABCs
- IV, O2, monitor
- Agitation
- Benzodiazepines
- Haldol for acute agitation
- Seizure
- Benzodiazepines
- manage airway as indicated
- Hyperthermia:
- ice packs, cold IVF
Disposition
- Admit pt's with complications of ingestion
See Also
Sources
Bersani FS, Corazza O, Albano G, et al. 25C-NBOMe: preliminary data on pharmacology, psychoactive effects, and toxicity of a new potent and dangerous hallucinogenic drug. Biomed Res Int. 2014;2014:734749.