25C-NBOMe: Difference between revisions
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*Other names: NBOMe-2C-C, Boom, C-Boom, Cimbi-82, Pandora, N-bomb, Holland film, Dime | *Other names: NBOMe-2C-C, Boom, C-Boom, Cimbi-82, Pandora, N-bomb, Holland film, Dime | ||
*Potent partial agonist of 5-HT2A receptor<ref name="pharm">Bersani FS, Corazza O, Albano G, et al. 25C-NBOMe: preliminary data on pharmacology, psychoactive effects, and toxicity of a new potent and dangerous hallucinogenic drug. Biomed Res Int. 2014;2014:734749.</ref> | *Potent partial agonist of 5-HT2A receptor<ref name="pharm">Bersani FS, Corazza O, Albano G, et al. 25C-NBOMe: preliminary data on pharmacology, psychoactive effects, and toxicity of a new potent and dangerous hallucinogenic drug. Biomed Res Int. 2014;2014:734749.</ref> | ||
*Member of new class of toxic phenethylamine derivatives (NBOMe) with similar effects to [[LSD]] | *Member of new class of toxic phenethylamine derivatives (NBOMe) with similar effects to [[LSD]] which is commonly ingested ingested orally or sublingually; can also be ingested nasally, parenterally, vaginally, rectally. | ||
*Dose of 50-200 micrograms causes hallucinogenic effects<ref name="pharm"></ref> | *Dose of 50-200 micrograms causes hallucinogenic effects<ref name="pharm"></ref> | ||
*Onset 0-15 mins, peak 30-90 mins, total duration 4-10 hours<ref name="pharm"></ref> | *Onset 0-15 mins, peak 30-90 mins, total duration 4-10 hours<ref name="pharm"></ref> | ||
*Case reports of ingestions have included overdose symptoms of grand mal seizures and purpuric rash and mydriasis with 25-'''B'''-NBOMe variant<ref>Poklis JL. et al. Determination of 4 bromo 2,5 dimethoxy N [2 methoxyphenyl) methyl] benzeneethanamine (25B NBOMe) in serum and urine by high performance liquid chromatography with tandem mass spectrometry in a case of severe intoxication. Drug Test Anal. 2004;6:764-9</ref> | |||
==Clinical Features== | ==Clinical Features== | ||
Revision as of 22:03, 18 December 2014
Background
- 2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
- Other names: NBOMe-2C-C, Boom, C-Boom, Cimbi-82, Pandora, N-bomb, Holland film, Dime
- Potent partial agonist of 5-HT2A receptor[1]
- Member of new class of toxic phenethylamine derivatives (NBOMe) with similar effects to LSD which is commonly ingested ingested orally or sublingually; can also be ingested nasally, parenterally, vaginally, rectally.
- Dose of 50-200 micrograms causes hallucinogenic effects[1]
- Onset 0-15 mins, peak 30-90 mins, total duration 4-10 hours[1]
- Case reports of ingestions have included overdose symptoms of grand mal seizures and purpuric rash and mydriasis with 25-B-NBOMe variant[2]
Clinical Features
- Metallic chemical taste
- Sense of numbness of tongue and mouth
- Euphoria
- Visual/Auditory hallucinations
- Stimulation +/- tremors, bruxism
- Serotonin Syndrome (AMS, Hyperthermia, rigidity, autonomic instability)[3]
- Confusion
- Agitation
- Vasoconstriction
- Nausea and Vomiting
- Headache
- Palpitations
- Diaphoresis
- Dysuria
- Hypertension
- Generalized Seizure
- Mydriasis
- Acute Renal Failure
- Metabolic Acidosis
Workup
Hallucination workup
- Urine pregnancy
- CBC, Metabolic panel, LFTs, coags, APAP level, ASA level
- Total CK level
- ECG
- UA
- Tox screen, blood alcohol
- Serum osmoles, urine Na (if Hyponatremia present)
- Head CT as indicated
- LP to rule out Meningitis if infectious symptoms and based on history and physical
Treatment
- ABCs
- IV, O2, monitor
- Agitation
- Benzodiazepines
- Haldol for acute agitation
- Seizure
- Benzodiazepines
- manage airway as indicated
- Hyperthermia:
- ice packs, cold IVF
Disposition
- Admit pt's with complications of ingestion
See Also
Sources
- ↑ 1.0 1.1 1.2 Bersani FS, Corazza O, Albano G, et al. 25C-NBOMe: preliminary data on pharmacology, psychoactive effects, and toxicity of a new potent and dangerous hallucinogenic drug. Biomed Res Int. 2014;2014:734749.
- ↑ Poklis JL. et al. Determination of 4 bromo 2,5 dimethoxy N [2 methoxyphenyl) methyl] benzeneethanamine (25B NBOMe) in serum and urine by high performance liquid chromatography with tandem mass spectrometry in a case of severe intoxication. Drug Test Anal. 2004;6:764-9
- ↑ Boyer EW, Shannon M. The serotonin syndrome. NEJM. 2005;352:1112-20