Rho(D) immune globulin

Background

• For fetal maternal hemorrhage
• Risk = >4-12wks
• Also given to male trauma patients who receive O+ blood to prevent future reaction with O+ transfusions

Treatment

1. 1st Trimester (through 12weeks)
   1. --> give 50 microgm IM
      1. (although there is no harm in giving the standard 300 microgram dose, which is more readily available)
2. 2nd & 3rd Trimester
   1. --> give 300 microgm IM once and send Kleihauer-Betke test
   2. --> within 72hrs give additional 300 microgm/15 ml Rh-positive blood

Exceptions

1. Prior sensitization of mother
2. Known Rh-negative father
3. Known Rh-negative fetus (from cord blood)

See Also

Vaginal Bleeding (Main)

Source

UpToDate