Anticoagulants: Difference between revisions
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==Contraindications to Anticoagulation<ref>Bates SM, Ginsberg JS. Treatment of deep-vein thrombosis. N Engl J Med. 2004;351(3):268–277.</ref> | |||
*Absolute: | |||
**Active bleeding | |||
**Severe bleeding diathesis or platelet count <20K | |||
**Neurosurgery, ocular surgery, or intracranial bleeding in the last 10 days | |||
*Relative: | |||
**Mild-to-moderate bleeding diathesis or thrombocytopenia | |||
**Brain metastases | |||
**Recent major trauma | |||
**Major abdominal surgery within the past 2 days | |||
**GI or GU bleeding within the past 14 days | |||
**Endocarditis | |||
**Severe hypertension (>200/120mmHg) at presentation | |||
==Vitamin K Antagonist== | ==Vitamin K Antagonist== | ||
Revision as of 23:16, 18 January 2021
==Contraindications to Anticoagulation[1]
- Absolute:
- Active bleeding
- Severe bleeding diathesis or platelet count <20K
- Neurosurgery, ocular surgery, or intracranial bleeding in the last 10 days
- Relative:
- Mild-to-moderate bleeding diathesis or thrombocytopenia
- Brain metastases
- Recent major trauma
- Major abdominal surgery within the past 2 days
- GI or GU bleeding within the past 14 days
- Endocarditis
- Severe hypertension (>200/120mmHg) at presentation
Vitamin K Antagonist
Blocks activation of vitamin K dependent prothrombotic factors II, VII, IX, X and blocks synthesis of vitamin K dependent ANTI-thrombotic proteins C and S
Heparins
Bind to and activate antithrombin, which in turns inactivates factor Xa and thrombin
Factor Xa Inhibitors
Inhibits Factor Xa, leading to inactivation of thrombin
- Rivaroxaban (Xarelto)
- Apixaban (Eliquis)
- Fondaparinux
- Edoxaban
Direct Thrombin Inhibitors
Self-explanatory
See Also
- ↑ Bates SM, Ginsberg JS. Treatment of deep-vein thrombosis. N Engl J Med. 2004;351(3):268–277.