Template:GHB background: Difference between revisions
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*Abbreviation: GHB | *Abbreviation: GHB | ||
*Central nervous system depressant | *Central nervous system depressant | ||
*GABA-B agonist (as opposed to GABA-A agonists - [[alcohol]], [[benzodiazepines]], etc) | |||
*Abused for: | *Abused for: | ||
**Body building or sleep enhancement | **Body building or sleep enhancement | ||
Revision as of 05:22, 28 January 2021
Background
- Abbreviation: GHB
- Central nervous system depressant
- GABA-B agonist (as opposed to GABA-A agonists - alcohol, benzodiazepines, etc)
- Abused for:
- Body building or sleep enhancement
- euphoric, sexual, stimulant, and relaxant effects
- Surreptitious drugging to facilitate sexual assault
Pharmacokinetics
- effect starts in 15-20min, peaks in 30-60 min,
- lipid soluble, no protein binding so crosses BBB readily
- elimination is dose-dependent with half life of 20-50 min
- The duration of GHB's clinical effects depends upon the dose, and ranges from 2.5 to 4 hours
Pharmacology
- Is a metabolite and precursor of GABA
- Interacts with GHB-specific receptors and also acts as a direct agonist of GABA-B receptors
- Affects multiple neurotransmitter systems, including those of opioids, dopamine, serotonin, glutamate, and acetylcholine
- Gamma butyrolactone (GBL) and 1,4 butanediol (BD) are GHB analogs that are rapidly metabolized to GHB after ingestion, with the same toxic and recreational effects