Hypermagnesemia: Difference between revisions
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==Background== | ==Background== | ||
High >3.5 | *High >3.5 | ||
*Magnesium is an effective calcium channel blocker both extracellularly and intracellularly<ref>Rizzo MA, Fisher M, Lock JP. Hypermagnesemic pseudocoma. Arch Intern Med. 1993;153(9):1130.</ref> | |||
*Intracellular magnesium profoundly blocks several cardiac potassium channels | |||
== | ==Clinical Features== | ||
* | *[[Nausea and vomiting]] | ||
* | *Loss of reflexes and [[respiratory failure|diaphragmatic paralysis]] (at very high levels) | ||
= | {| class="wikitable" | ||
|- | |||
! Mg Level !! Signs/Symptoms | |||
|- | |||
| 2-3 || [[Nausea]] | |||
|- | |||
| 3-4 || [[Somnolence]] | |||
|- | |||
| 4-8 || Loss of DTRs, muscle weakness | |||
|- | |||
| 8-12 || Respiratory depression | |||
|- | |||
| 12-15 || [[Hypotension]], [[heart block]], [[Cardiac Arrest]], death | |||
|} | |||
== | ==Differential Diagnosis== | ||
*[[Renal Failure]] | |||
*[[Lithium]] | |||
*[[hypovolemia|Volume depletion]] | |||
*[[Rhabdo]] | |||
*IV Mg (goal in PET/[[eclampsia]] 5-7 mEq/L) | |||
*Massive PO intake ([[bulimia nervosa|laxative abusers]], accidental Epsom salts) | |||
*Magnesium enemas<ref>Schelling Fatal hypermagnesemia. JR1. Clin Nephrol. 2000 Jan;53(1):61-5.</ref> | |||
== | ==Evaluation== | ||
*Magnesium level >3.5 | |||
==Management== | |||
*[[IVF]] | |||
*[[Furosemide]] 20-40mg IV | |||
*[[Calcium chloride]] 10% 5-10mL IV or [[calcium gluconate]] 10% 15-30mL IV over 5min | |||
*Consider hemodialysis for Mg >8 or poor renal function | |||
==Disposition== | |||
==See Also== | |||
*[[Electrolyte Abnormalities (Main)]] | |||
*[[Hypomagnesemia]] | |||
*[[Preeclampsia]] | |||
*[[QT prolongation]] | |||
==References== | |||
<references/> | |||
[[Category:FEN]] | [[Category:FEN]] | ||
[[Category:Toxicology]] | |||
Latest revision as of 23:35, 23 February 2021
Background
- High >3.5
- Magnesium is an effective calcium channel blocker both extracellularly and intracellularly[1]
- Intracellular magnesium profoundly blocks several cardiac potassium channels
Clinical Features
- Nausea and vomiting
- Loss of reflexes and diaphragmatic paralysis (at very high levels)
| Mg Level | Signs/Symptoms |
|---|---|
| 2-3 | Nausea |
| 3-4 | Somnolence |
| 4-8 | Loss of DTRs, muscle weakness |
| 8-12 | Respiratory depression |
| 12-15 | Hypotension, heart block, Cardiac Arrest, death |
Differential Diagnosis
- Renal Failure
- Lithium
- Volume depletion
- Rhabdo
- IV Mg (goal in PET/eclampsia 5-7 mEq/L)
- Massive PO intake (laxative abusers, accidental Epsom salts)
- Magnesium enemas[2]
Evaluation
- Magnesium level >3.5
Management
- IVF
- Furosemide 20-40mg IV
- Calcium chloride 10% 5-10mL IV or calcium gluconate 10% 15-30mL IV over 5min
- Consider hemodialysis for Mg >8 or poor renal function