Doxylamine: Difference between revisions
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==Administration== | ==Administration== | ||
*Type: Antihistamine | *Type: [[Antihistamine]] | ||
*Dosage Forms: | *Dosage Forms: | ||
*Routes of Administration: oral | *Routes of Administration: oral | ||
| Line 7: | Line 7: | ||
==Adult Dosing== | ==Adult Dosing== | ||
*Rhinitis: 7.5-12.5mg PO q4-6h | *Rhinitis: 7.5-12.5mg PO q4-6h | ||
*Insomnia: 25-50mg PO | *[[Insomnia]]: 25-50mg PO | ||
*Nausea in pregnancy/hyperemesis gravidarum: 12.5mg q6-8hrs | *[[Nausea in pregnancy]]/[[hyperemesis gravidarum]]: 12.5mg q6-8hrs (often used in combination with [[pyridoxine]]) | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
'''Not recommended for children <12 yo due to tendency to paradoxical reactions''' | '''Not recommended for children <12 yo due to tendency to paradoxical reactions''' | ||
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==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*[[Anticholinergic toxicity]] | |||
===Common=== | ===Common=== | ||
| Line 31: | Line 33: | ||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: 10-18h | *Half-life: 10-18h | ||
*Metabolism: Hepatic | *Metabolism: Hepatic - CYP450 | ||
*Excretion: | *Excretion: Urine | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
| Line 41: | Line 43: | ||
==See Also== | ==See Also== | ||
*[[Antihistamines]] | *[[Antihistamines]] | ||
*[[Anticholinergic toxicity]] | |||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
Latest revision as of 22:29, 7 March 2021
Administration
- Type: Antihistamine
- Dosage Forms:
- Routes of Administration: oral
- Common Trade Names: Unisom
Adult Dosing
- Rhinitis: 7.5-12.5mg PO q4-6h
- Insomnia: 25-50mg PO
- Nausea in pregnancy/hyperemesis gravidarum: 12.5mg q6-8hrs (often used in combination with pyridoxine)
Pediatric Dosing
Not recommended for children <12 yo due to tendency to paradoxical reactions
- 2-6yo: 1.9 to 3.125 mg q4-6h
- 6-12 yo: 3.75 to 6.25 mg q4-6h
Special Populations
- Pregnancy Rating: A
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: no adjustment
- Hepatic dosing: no adjustment
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
- Somnolence
Pharmacology
- Half-life: 10-18h
- Metabolism: Hepatic - CYP450
- Excretion: Urine
Mechanism of Action
- H1-histamine blocker