Troponin: Difference between revisions
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==Background== | |||
*during contraction of muscle- thick filaments of myosin slide past thin filaments of actin by calcium mediated atp dependent contraction. Released calcium binds to troponin C, T, and I, which regulate muscle contraction. | |||
*troponins not change in trauma, skeletal muscle dz, exercise, renal failure like ck does. | |||
*troponin C found in all tissue and is not cardiac marker | |||
*troponin T is qualitative assay. | |||
*troponin I is quantitative assay. | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
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*[[Sepsis]] | *[[Sepsis]] | ||
*[[Dissection]] | *[[Dissection]] | ||
*Arrhythmias | *[[Arrhythmias]] | ||
*[[CVA]] | *[[CVA]] | ||
*[[SAH]] | *[[SAH]] | ||
| Line 15: | Line 21: | ||
*[[Acute Renal Failure|Renal failure]] | *[[Acute Renal Failure|Renal failure]] | ||
**Assume true positive until proven otherwise | **Assume true positive until proven otherwise | ||
*Cardioversion | *[[Cardioversion]] | ||
*Cardiotoxic meds | *Cardiotoxic meds | ||
*Amyloidosis | *[[Amyloidosis]] | ||
*Rheumatoid Factor | *Rheumatoid Factor | ||
*Heterophilic antibodies | *Heterophilic antibodies | ||
Revision as of 20:27, 2 February 2015
Background
- during contraction of muscle- thick filaments of myosin slide past thin filaments of actin by calcium mediated atp dependent contraction. Released calcium binds to troponin C, T, and I, which regulate muscle contraction.
- troponins not change in trauma, skeletal muscle dz, exercise, renal failure like ck does.
- troponin C found in all tissue and is not cardiac marker
- troponin T is qualitative assay.
- troponin I is quantitative assay.
Differential Diagnosis
False (Non-CAD) Positives
- Pericarditis
- PE
- CHF
- Sepsis
- Dissection
- Arrhythmias
- CVA
- SAH
- Burns
- Renal failure
- Assume true positive until proven otherwise
- Cardioversion
- Cardiotoxic meds
- Amyloidosis
- Rheumatoid Factor
- Heterophilic antibodies
See Also
Source
Tintinalli