Ascites: Difference between revisions
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*Abnormal buildup of peritoneal fluid | *Abnormal buildup of peritoneal fluid | ||
*Most commonly caused by portal hypertension | *Most commonly caused by portal hypertension | ||
*Ascites fluid can become infected ( | *Ascites fluid can become infected (spontaneous bacterial peritonitis), carrying a mortality rate between 30%-90%<ref>Sundaram V, Manne V, Al-Osaimi AM. Ascites and spontaneous bacterial peritonitis: recommendations from two United States centers. Saudi J Gastroenterol. 2014;20(5):279-287. doi:10.4103/1319-3767.141686</ref> | ||
===Causes=== | ===Causes=== | ||
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[[File:Ascites Alerhand.gif|thumbnail|POCUS showing ascites<ref>http://www.thepocusatlas.com/bowel/</ref>]] | [[File:Ascites Alerhand.gif|thumbnail|POCUS showing ascites<ref>http://www.thepocusatlas.com/bowel/</ref>]] | ||
[[File:CirrhosisWithAscitesMark.png|thumb|Liver cirrhosis with ascites on CT]] | [[File:CirrhosisWithAscitesMark.png|thumb|Liver cirrhosis with ascites on CT]] | ||
*Ascites in females with no other reason = | *Ascites in females with no other reason for it = gyn neoplasm until proven otherwise (ovarian cancer) | ||
===Workup=== | ===Workup=== | ||
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*[[FAST]] | *[[FAST]] | ||
==== | ====Ascites Fluid Workup==== | ||
*Cell count and differential | *Cell count and differential | ||
*Albumin | *Albumin | ||
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*[[Cirrhosis]] | *[[Cirrhosis]] | ||
*[[Acute hepatic failure]] | *[[Acute hepatic failure]] | ||
==References== | ==References== | ||
Revision as of 15:51, 6 October 2021
Background
- Abnormal buildup of peritoneal fluid
- Most commonly caused by portal hypertension
- Ascites fluid can become infected (spontaneous bacterial peritonitis), carrying a mortality rate between 30%-90%[1]
Causes
- Cirrhosis 81%[2]
- Malignancy 10%
- Heart failure 3%
- Tuberculosis 2%
- Other 4%
Clinical Features
- Abdominal distention +/- discomfort
- Fluid wave
- +/- SOB if massive amount
Differential Diagnosis
Abdominal distention
- Obesity
- Intestinal obstruction
- Pregnancy
- Ascites
- Cirrhosis
- Malignancy
- Heart failure
- Tuberculosis
- Spontaneous bacterial peritonitis
- Peritoneal dialysis-associated peritonitis
- Distended bladder / Acute urinary retention
- Constipation / fecal impaction
- Large tumor(s) (e.g. ovarian, lymphoma)
- Organomegaly
Evaluation
POCUS showing ascites[3]
- Ascites in females with no other reason for it = gyn neoplasm until proven otherwise (ovarian cancer)
Workup
Ascites Fluid Workup
- Cell count and differential
- Albumin
- Total protein
- Only if suspicious:[4]
- Gram stain
- Glucose
- LDH
- Amylase
- AFB smear and culture
- Cytology
- Triglyceride
Ascites Diagnosis
The differential diagnosis of ascites is often clarified by the calculation of the serum albumin to ascites gradient (SAAG).^
- High SAAG > 1.1 g/dL – Indicative of portal hypertension[5]
- Cirrhosis
- Heart failure
- Ascites total protein > 2.5 g/dL suggests cardiac ascites[6]
- Alcoholic hepatitis
- Budd-Chiari syndrome
- Portal vein thrombosis
- Low SAAG < 1.1 g/dL
- Malignancy / peritoneal carcinomatosis
- Nephrotic syndrome
- Pancreatitis
- Peritoneal tuberculosis
- Serositis
- Bowel infarction
- Chylous
- ^SAAG = (serum albumin in g/dL) − (ascitic albumin in g/dL)
Management
- Salt restriction
- Effective in about 15% of patients
- Diuretics
- Spironolactone
- Starting dose = 100mg/day PO (max 400mg/day)
- 40% of patients will respond
- Furosemide
- 40mg/day PO (max 160mg/day)
- Ratio of 100:40 with spironolactone (reduces risks of potassium prob)
- Spironolactone
- Water restriction
- Paracentesis
- Consider liver transplantation and shunting
Disposition
- Frequently outpatient, once SBP is ruled out, if a known reason for ascites and sufficiently therapeutically drained
Complications
See Also
References
- ↑ Sundaram V, Manne V, Al-Osaimi AM. Ascites and spontaneous bacterial peritonitis: recommendations from two United States centers. Saudi J Gastroenterol. 2014;20(5):279-287. doi:10.4103/1319-3767.141686
- ↑ Runyon BA. Care of patients with ascites. N Eng J Med. 1994; 330: 337-342.
- ↑ http://www.thepocusatlas.com/bowel/
- ↑ Runyon BA. Management of adult patients with ascites due to cirrhosis: update 2012. Amer Assoc Study Liv Dis. 2012; 1-96.
- ↑ Runyon BA. Management of adult patients with ascites due to cirrhosis: update 2012. Amer Assoc Study Liv Dis. 2012; 1-96.
- ↑ Runyon BA. Cardiac ascites: a characterization. J Clin Gastro. 1998; 10(4): 410-412.