Fentanyl: Difference between revisions
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==General== | ==General== | ||
*Type: [[ | *Type: [[Opioids]] | ||
*Dosage Forms: | *Dosage Forms: IV, intranasal, transdermal | ||
*Common Trade Names: | *Common Trade Names: Sublimaze | ||
==Adult Dosing== | ==Adult Dosing== | ||
*Analgesia: 1-2 mcg/kg IV/IM, q30-60 min PRN | |||
*Sedation: 1-3 mcg/kg/hr continuous infusion | |||
*Dosing based off total body weight | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*0.5-2 mcg/kg IV/IN q1-2 hr | |||
==Special Populations== | ==Special Populations<ref>Fentanyl: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. </ref>== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C | ||
*Lactation: | *Lactation: Excreted in breast milk, not recommended | ||
*Renal Dosing | *Renal Dosing | ||
**Adult | **Adult | ||
*** Not defined | |||
**Pediatric | **Pediatric | ||
*** Not defined but recommendations for IV: | |||
**** GFR > 50 mL/minute/1.73 m²: no adjustment | |||
**** GFR 10 to 50 mL/minute/1.73 m²: 75% of usual dose | |||
**** GFR < 10 mL/minute/1.73 m²: 50% of usual dose | |||
**** Hemodialysis: 50% of usual dose | |||
*Hepatic Dosing | *Hepatic Dosing | ||
**Adult | **Adult | ||
*** Not defined | |||
**Pediatric | **Pediatric | ||
*** Not defined | |||
==Contraindications== | ==Contraindications== | ||
| Line 23: | Line 35: | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*Apnea | |||
===Common=== | ===Common=== | ||
*Confusion | |||
*Constipation | |||
*Nausea/Vomiting | |||
*Somnolence | |||
*Sweating | |||
*Asthenia | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 2-4 hours | ||
*Metabolism: | *Metabolism: Hepatic | ||
*Excretion: | *Excretion: Renal | ||
*Mechanism of Action: | *Mechanism of Action: Narcotic opiate receptor agonist | ||
==See Also== | ==See Also== | ||
*[[Intranasal sedation]] | |||
== | ==References== | ||
<references/> | <references/> | ||
[[Category: | [[Category:Pharmacology]] | ||
Latest revision as of 09:23, 3 January 2022
General
- Type: Opioids
- Dosage Forms: IV, intranasal, transdermal
- Common Trade Names: Sublimaze
Adult Dosing
- Analgesia: 1-2 mcg/kg IV/IM, q30-60 min PRN
- Sedation: 1-3 mcg/kg/hr continuous infusion
- Dosing based off total body weight
Pediatric Dosing
- 0.5-2 mcg/kg IV/IN q1-2 hr
Special Populations[1]
- Pregnancy Rating: C
- Lactation: Excreted in breast milk, not recommended
- Renal Dosing
- Adult
- Not defined
- Pediatric
- Not defined but recommendations for IV:
- GFR > 50 mL/minute/1.73 m²: no adjustment
- GFR 10 to 50 mL/minute/1.73 m²: 75% of usual dose
- GFR < 10 mL/minute/1.73 m²: 50% of usual dose
- Hemodialysis: 50% of usual dose
- Not defined but recommendations for IV:
- Adult
- Hepatic Dosing
- Adult
- Not defined
- Pediatric
- Not defined
- Adult
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Apnea
Common
- Confusion
- Constipation
- Nausea/Vomiting
- Somnolence
- Sweating
- Asthenia
Pharmacology
- Half-life: 2-4 hours
- Metabolism: Hepatic
- Excretion: Renal
- Mechanism of Action: Narcotic opiate receptor agonist
See Also
References
- ↑ Fentanyl: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.