Prednisone: Difference between revisions
| Line 49: | Line 49: | ||
0.05-2mg/kg/day PO divided qd-qid | 0.05-2mg/kg/day PO divided qd-qid | ||
Dose varies based on condition | Dose varies based on condition | ||
*Asthma, acute | *Asthma, acute | ||
1-2 mg/day PO divided qd-bid Max 60mg/day | 1-2 mg/day PO divided qd-bid Max 60mg/day | ||
If patient can tolerate PO, no need to give steroids IV, but if asthma is severe, and Bipap / intubation likely, best to keep patient NPO and give methylprednisolone IV | If patient can tolerate PO, no need to give steroids IV, but if asthma is severe, and Bipap / intubation likely, best to keep patient NPO and give methylprednisolone IV | ||
*Adrenal Insufficiency | *Adrenal Insufficiency | ||
4-5mg/ m^2 PO qd Taper dose gradually to d/c when appropriate | 4-5mg/ m^2 PO qd Taper dose gradually to d/c when appropriate | ||
*Nephrotic Syndrome | *Nephrotic Syndrome | ||
2mg / kg PO qd | 2mg / kg PO qd | ||
Max 80 mg / day. Use for 1st 3 episodes | Max 80 mg / day. Use for 1st 3 episodes | ||
*PCP, adjunct tx | *PCP, adjunct tx | ||
(children <40kg) | (children <40kg) | ||
1mg/kg PO bid x5days, then 0.5mg/kg PO bid x5days, then 0.5mg PO qd x 11 days. Start w/in 72 hrs of antimicrobial tx | 1mg/kg PO bid x5days, then 0.5mg/kg PO bid x5days, then 0.5mg PO qd x 11 days. Start w/in 72 hrs of antimicrobial tx | ||
(Children >40kg) | (Children >40kg) | ||
40mg PO bid x5 days, then 20mg PO bid x5 days, then 20mg PO qd x 11 days. Start w/in 72 hrs of antimicrobial tx | 40mg PO bid x5 days, then 20mg PO bid x5 days, then 20mg PO qd x 11 days. Start w/in 72 hrs of antimicrobial tx | ||
(Adolescents) | (Adolescents) | ||
40mg PO bid x5 days, then 40mg PO qd x5 days, then 20mg PO qd x 11 days. Start w/in 72 hrs of antimicrobial tx | 40mg PO bid x5 days, then 40mg PO qd x5 days, then 20mg PO qd x 11 days. Start w/in 72 hrs of antimicrobial tx | ||
*Renal Dosing | *Renal Dosing | ||
Revision as of 19:37, 16 March 2015
General
- Type:
- Dosage Forms:1, 2, 5, 10, 20, 50, 5/5ml
- Common Trade Names: Sterapred, Sterapred DS, Rayos
Adult Dosing
For all doses of prednisone, it is best given with food. Also, ideally best when given in AM to coincide with natural cortisol release. No need to taper if short course less than 1 week, otherwise consider taper.
- Corticosteroid-responsive conditions
5-60mg PO qd Dose varies based on condition
- Asthma, acute
40-80 mg/day PO divided qd-bid (most practitioners give 60mg po x 1 to 80-100kg adult) If patient can tolerate PO, no need to give steroids IV, but if asthma is severe, and bipap / intubation likely, best to keep patient NPO and give methylprednisolone IV
- Adrenal Insufficiency
4-5mg/ m^2 PO qd Taper dose gradually to d/c when appropriate
- Multiple Sclerosis, acute exacerbation
200mg PO qd x1 week, then 80mg po qod x1 mo Give with food, also prescribe PPI for gastric protection. Taper dose gradually to d/c
- Alcoholic Hepatitis, acute
40mg PO qd
- PCP, Adjunct tx
40mg PO bid x5 days, then 40mg PO qd x5 days, then 20mg PO qd x11 days Start w/in 72hrs of antimicrobial tx Always consider discussion with HIV consultants prior to given steroids, as they will be managing patient in hospital
- Renal Dosing
No adjustment
- Hepatic Dosing
Not defined
Pediatric Dosing
For all doses of prednisone, it is best tolerated with food. Ideally best when given in AM to coincide with natural cortisol release. No need to taper if short course less than 1 week, otherwise consider taper.
- Corticosteroid-responsive conditions
0.05-2mg/kg/day PO divided qd-qid Dose varies based on condition
- Asthma, acute
1-2 mg/day PO divided qd-bid Max 60mg/day If patient can tolerate PO, no need to give steroids IV, but if asthma is severe, and Bipap / intubation likely, best to keep patient NPO and give methylprednisolone IV
- Adrenal Insufficiency
4-5mg/ m^2 PO qd Taper dose gradually to d/c when appropriate
- Nephrotic Syndrome
2mg / kg PO qd Max 80 mg / day. Use for 1st 3 episodes
- PCP, adjunct tx
(children <40kg) 1mg/kg PO bid x5days, then 0.5mg/kg PO bid x5days, then 0.5mg PO qd x 11 days. Start w/in 72 hrs of antimicrobial tx
(Children >40kg)
40mg PO bid x5 days, then 20mg PO bid x5 days, then 20mg PO qd x 11 days. Start w/in 72 hrs of antimicrobial tx
(Adolescents)
40mg PO bid x5 days, then 40mg PO qd x5 days, then 20mg PO qd x 11 days. Start w/in 72 hrs of antimicrobial tx
- Renal Dosing
No adjustment
- Hepatic Dosing
Not defined
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action: