Mannitol: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
[http://www.medicinenet.com/mannitol-injectable/article.htm 0.25-2 G/kg given every 6 to 8 hours] | |||
Main ED indication is for lowering ICP with signs of impending herniation or severely deteriorating mental status in context of known trauma or intracranial lesion exerting mass effect. | |||
[http://www.cochrane.org/CD001049/INJ_mannitol-for-acute-traumatic-brain-injury Recent cochrane review showed that Mannitol should be given as more likely a one time bolus, and may be inferior to Hypertonic Saline] | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Revision as of 17:09, 19 March 2015
General
- Type: Sugar Alcohol, derived from mannose, stereo-isomer of sorbitol
- Dosage Forms: Reconstituted powder and solution, 5% and 10% in 1000 ml containers; 15% in 500 ml containers, 20% in 250 ml and 500 ml containers; and 25% in 50 ml flip-top vials. IV
- Common Trade Names: Mannitol, Osmitrol
Adult Dosing
0.25-2 G/kg given every 6 to 8 hours
Main ED indication is for lowering ICP with signs of impending herniation or severely deteriorating mental status in context of known trauma or intracranial lesion exerting mass effect.
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action: