Mannitol: Difference between revisions
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==Pediatric Dosing== | ==Pediatric Dosing== | ||
===Cerebral edema=== | |||
*0.25-1 g/kg IV initially; maintenance dose of 0.25-0.5 g/kg IV q4-6hr<ref>http://reference.medscape.com/drug/osmitrol-mannitol-343061</ref> | |||
==Special Populations== | ==Special Populations== | ||
Revision as of 14:48, 21 March 2015
General
- Type: Sugar Alcohol, derived from mannose, stereo-isomer of sorbitol
- Dosage Forms: Reconstituted powder and solution, 5% and 10% in 1000 ml containers; 15% in 500 ml containers, 20% in 250 ml and 500 ml containers; and 25% in 50 ml flip-top vials; IV[1]
- Common Trade Names: Mannitol, Osmitrol
Adult Dosing
Elevated intracranial pressure
- 0.25-2 G/kg given every 6 to 8 hours[2]
- Should be given as a one time bolus (may be inferior to Hypertonic Saline)[3]
Pediatric Dosing
Cerebral edema
- 0.25-1 g/kg IV initially; maintenance dose of 0.25-0.5 g/kg IV q4-6hr[4]
Special Populations
- Pregnancy Rating: C
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Indications
- Lowering ICP with signs of impending herniation or severely deteriorating mental status in context of known trauma or intracranial lesion exerting mass effect
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action: