Acetaminophen: Difference between revisions

Latest revision as of 21:32, 16 January 2025

General

Type: Antipyretic
Dosage Forms: IV; PO (160 mg/5 mL); PR
Common Trade Names: Tylenol, Paracetamol, Acephen

Adult Dosing

General

PO
- Immediate-release
  - Regular strength: 650mg q4-6 hours
  - Extra strength: 1000mg q6 hours
- Extended-release: 1300mg q8 hours
Rectal: 650mg q4-6 hours
IV:
- <50 kg: 15mg/kg q6 hours or 12.5mg/kg q4 hours
- ≥50 kg: 650mg q4 hours or 1000mg q6 hours
Maximum daily dose: 4g

Pediatric Dosing

15mg/kg/dose q6 hours

Acetaminophen Pediatric Dosing Chart

Weight (kg)	Weight (lbs)	Age	Dosage (mg)
3-4	6-11	0-3 mo	40
5-7	12-17	4-11 mo	80
8-10	18-23	1-2 y	120
11-15	24-35	2-3 y	160
16-21	36-47	4-5 y	240
22-26	48-59	6-8 y	320
27-32	60-71	9-10 y	400
33-43	72-95	11 y	480

Dosage can be given q6 hours

Special Populations

Pregnancy Rating: B
Lactation Risk Categories: safe
Renal Dosing
- Adult: CrCl 10-50: give q6h, CrCl <10: give q8h
- Pediatric: CrCl 10-50: give q6h, CrCl <10: give q8h
Hepatic Dosing
- Adult: not defined
- Pediatric: not defined

Contraindications

Allergy to class/drug

Adverse Reactions

Serious

Common

Warnings

When calculating maximum daily dose consider all sources of acetaminophen
Be careful that the dose in milligrams and milliliters is not confused

Pharmacology

Half-life: 2-4 hour
Metabolism: Liver
Excretion: urine
Mechanism of Action: antipyretic effect via direct action on the hypothalamic heat-regulating center

References

Acephen (acetaminophen suppositories) [prescribing information]. South Plainfield, NJ: G&W Laboratories; April 2014.

Authors:

@@ Line 1: / Line 1: @@
 ==General==
-*Type:
+*Type: Antipyretic
-*Dosage Forms:
+*Dosage Forms: IV; PO (160 mg/5 mL); PR
-*Common Trade Names: Tylenol
+*Common Trade Names: Tylenol, Paracetamol, Acephen
 ==Adult Dosing==
@@ Line 8: / Line 8: @@
 *PO
 **Immediate-release
-***Regular strength: 650 mg q4-6 hours
+***Regular strength: 650mg q4-6 hours
-***Extra strength: 1000 mg q6 hours
+***Extra strength: 1000mg q6 hours
-**Extended-release: 1300 mg q8 hours
+**Extended-release: 1300mg q8 hours
-*Rectal: 650 mg q4-6 hours
+*Rectal: 650mg q4-6 hours
 *IV:
-**<50 kg: 15 mg/kg q6 hours or 12.5 mg/kg q4 hours
+**<50 kg: 15mg/kg q6 hours or 12.5mg/kg q4 hours
-**≥50 kg: 650 mg q4 hours or 1000 mg q6 hours
+**≥50 kg: 650mg q4 hours or 1000mg q6 hours
 *Maximum daily dose: 4g
 ==Pediatric Dosing==
-*15 mg/kg/dose Q6 hours
+*15mg/kg/dose q6 hours
+{{Acetaminophen pediatric dosing chart}}
 ==Special Populations==
-*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
+*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B
-*Lactation:
+*[[Lactation Risk Categories]]: safe
 *Renal Dosing
-**Adult
+**Adult: CrCl 10-50: give q6h, CrCl <10: give q8h
-**Pediatric
+**Pediatric: CrCl 10-50: give q6h, CrCl <10: give q8h
 *Hepatic Dosing
-**Adult
+**Adult: not defined
-**Pediatric
+**Pediatric: not defined
 ==Contraindications==
@@ Line 35: / Line 37: @@
 ==Adverse Reactions==
 ===Serious===
-*[[Acetaminophen (tylenol) toxicity]]
+*[[Acetaminophen toxicity]]
+*[[Anemia]]
+*[[Thrombocytopenia]]
 ===Common===
+*[[Nausea]]
+*[[Rash]]
+*[[Headache]]
 ==Warnings==
@@ Line 44: / Line 51: @@
 ==Pharmacology==
-*Half-life:
+*Half-life: 2-4 hour
-*Metabolism:
+*Metabolism: Liver
-*Excretion:
+*Excretion: urine
-*Mechanism of Action:
+*Mechanism of Action: antipyretic effect via direct action on the hypothalamic heat-regulating center
 ==See Also==
-*[[Acetaminophen (tylenol) toxicity]]
+*[[Acetaminophen toxicity]]
-==Sources==
+==References==
+*Acephen (acetaminophen suppositories) [prescribing information]. South Plainfield, NJ: G&W Laboratories; April 2014.
 <references/>
-[[Category:Drugs]]
+[[Category:Pharmacology]]