Acetaminophen: Difference between revisions
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==General== | ==General== | ||
*Type: Antipyretic | *Type: Antipyretic | ||
*Dosage Forms: IV; PO; PR | *Dosage Forms: IV; PO (160 mg/5 mL); PR | ||
*Common Trade Names: Tylenol, Paracetamol | *Common Trade Names: Tylenol, Paracetamol, Acephen | ||
==Adult Dosing== | ==Adult Dosing== | ||
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*PO | *PO | ||
**Immediate-release | **Immediate-release | ||
***Regular strength: | ***Regular strength: 650mg q4-6 hours | ||
***Extra strength: | ***Extra strength: 1000mg q6 hours | ||
**Extended-release: | **Extended-release: 1300mg q8 hours | ||
*Rectal: | *Rectal: 650mg q4-6 hours | ||
*IV: | *IV: | ||
**<50 kg: | **<50 kg: 15mg/kg q6 hours or 12.5mg/kg q4 hours | ||
**≥50 kg: | **≥50 kg: 650mg q4 hours or 1000mg q6 hours | ||
*Maximum daily dose: 4g | *Maximum daily dose: 4g | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
* | *15mg/kg/dose q6 hours | ||
{{Acetaminophen pediatric dosing chart}} | {{Acetaminophen pediatric dosing chart}} | ||
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==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B | ||
*Lactation: safe | *[[Lactation Risk Categories]]: safe | ||
*Renal Dosing | *Renal Dosing | ||
**Adult: CrCl 10-50: give q6h, CrCl <10: give q8h | **Adult: CrCl 10-50: give q6h, CrCl <10: give q8h | ||
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==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*[[Acetaminophen | *[[Acetaminophen toxicity]] | ||
*Anemia | *[[Anemia]] | ||
*Thrombocytopenia | *[[Thrombocytopenia]] | ||
===Common=== | ===Common=== | ||
*Nausea | *[[Nausea]] | ||
*Rash | *[[Rash]] | ||
*Headache | *[[Headache]] | ||
==Warnings== | ==Warnings== | ||
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==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 2-4 hour | ||
*Metabolism: | *Metabolism: Liver | ||
*Excretion: | *Excretion: urine | ||
*Mechanism of Action: | *Mechanism of Action: antipyretic effect via direct action on the hypothalamic heat-regulating center | ||
==See Also== | ==See Also== | ||
*[[Acetaminophen | *[[Acetaminophen toxicity]] | ||
== | ==References== | ||
*Acephen (acetaminophen suppositories) [prescribing information]. South Plainfield, NJ: G&W Laboratories; April 2014. | |||
<references/> | <references/> | ||
[[Category: | |||
[[Category:Pharmacology]] | |||
Latest revision as of 21:32, 16 January 2025
General
- Type: Antipyretic
- Dosage Forms: IV; PO (160 mg/5 mL); PR
- Common Trade Names: Tylenol, Paracetamol, Acephen
Adult Dosing
General
- PO
- Immediate-release
- Regular strength: 650mg q4-6 hours
- Extra strength: 1000mg q6 hours
- Extended-release: 1300mg q8 hours
- Immediate-release
- Rectal: 650mg q4-6 hours
- IV:
- <50 kg: 15mg/kg q6 hours or 12.5mg/kg q4 hours
- ≥50 kg: 650mg q4 hours or 1000mg q6 hours
- Maximum daily dose: 4g
Pediatric Dosing
- 15mg/kg/dose q6 hours
Acetaminophen Pediatric Dosing Chart
| Weight (kg) | Weight (lbs) | Age | Dosage (mg) |
| 3-4 | 6-11 | 0-3 mo | 40 |
| 5-7 | 12-17 | 4-11 mo | 80 |
| 8-10 | 18-23 | 1-2 y | 120 |
| 11-15 | 24-35 | 2-3 y | 160 |
| 16-21 | 36-47 | 4-5 y | 240 |
| 22-26 | 48-59 | 6-8 y | 320 |
| 27-32 | 60-71 | 9-10 y | 400 |
| 33-43 | 72-95 | 11 y | 480 |
- Dosage can be given q6 hours
Special Populations
- Pregnancy Rating: B
- Lactation Risk Categories: safe
- Renal Dosing
- Adult: CrCl 10-50: give q6h, CrCl <10: give q8h
- Pediatric: CrCl 10-50: give q6h, CrCl <10: give q8h
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Warnings
- When calculating maximum daily dose consider all sources of acetaminophen
- Be careful that the dose in milligrams and milliliters is not confused
Pharmacology
- Half-life: 2-4 hour
- Metabolism: Liver
- Excretion: urine
- Mechanism of Action: antipyretic effect via direct action on the hypothalamic heat-regulating center
See Also
References
- Acephen (acetaminophen suppositories) [prescribing information]. South Plainfield, NJ: G&W Laboratories; April 2014.