Chlordiazepoxide: Difference between revisions
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==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Time to peak: 0.5-2 h | ||
*Metabolism: | *Half-life: Parent compound 6-28 h, demoxepam (metabolite) 14-95 h | ||
*Excretion: | *Metabolism: Hepatic to desmethyldiazepam (active), desmethylchlordiazepoxide, demoxepam | ||
*Mechanism of Action: | *Excretion: Urine | ||
*Mechanism of Action: [[Benzodiazepines]] | |||
==See Also== | ==See Also== | ||
Revision as of 18:25, 26 May 2015
General
- Type: Benzodiazepines
- Dosage Forms: 5,10, 25 mg tab
- Common Trade Names: Librium
Adult Dosing
- EtOH withdrawal
- Example taper:
- Day 1: 50 mg q6h
- Day 2: 25 mg q6h
- Day 3: 25 mg q12h
- Day 4: 25 mg at night
- Max 300 mg per 24 hours
- Example taper:
Pediatric Dosing
- N/A
Special Populations
- Pregnancy Rating: Category D
- Lactation: Enters breast milk, not recommended
- Renal Dosing: CrCl < 10 cc/min : 1/2 normal dose
- Hepatic Dosing: No specific guidelines. Use caution as hepatically metabolized
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- CNS depression
- Paradoxical agitation
- Drug induced EPS
- Bone marrow suppression, agranulocytosis
Common
- Drowsiness
Pharmacology
- Time to peak: 0.5-2 h
- Half-life: Parent compound 6-28 h, demoxepam (metabolite) 14-95 h
- Metabolism: Hepatic to desmethyldiazepam (active), desmethylchlordiazepoxide, demoxepam
- Excretion: Urine
- Mechanism of Action: Benzodiazepines