Fresh frozen plasma

Features

1. Contains all coagulation factors and fibrinogen
   1. 40 mL/kg raises any factor by 100% (each unit is ~200mL)
2. May cause fluid overload
3. ABO compatibilty a must but crossmatch before transfusing not
4. INR of FFP is ~1.2
5. Retains active coagulation factors for up to 5 days after being thawed

Indications

1. Rapid reversal of warfarin over-anticoagulation
2. Bleeding and multiple coagulation defects
3. Correction of coagulation defects for which no specific factor is available
4. Transfusion of more than one blood volume w/ evidence of active bleeding + coagulopathy

Dose

1. Transfuse at least 15 mL/kg at a time (4 units in 70-kg adult)

See Also

• Transfusions

Source

Tintinalli