Fresh frozen plasma: Difference between revisions
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== | ==General== | ||
*Type: [[Blood products]] | |||
*Dosage Forms: | |||
*Common Trade Names: | |||
==Adult Dosing== | |||
*Transfuse at least 15 mL/kg at a time (4 units in 70-kg adult) | |||
==Pediatric Dosing== | |||
==Special Populations== | |||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | |||
*Lactation: | |||
*Renal Dosing | |||
**Adult | |||
**Pediatric | |||
*Hepatic Dosing | |||
**Adult | |||
**Pediatric | |||
==Indications== | ==Indications== | ||
*Rapid reversal of warfarin over-anticoagulation | |||
*Bleeding and multiple coagulation defects | |||
*Correction of coagulation defects for which no specific factor is available | |||
*Transfusion of more than one blood volume w/ evidence of active bleeding + coagulopathy | |||
==Contraindications== | |||
*Allergy to class/drug | |||
==Adverse Reactions== | |||
===Serious=== | |||
===Common=== | |||
==Pharmacology== | |||
*Half-life: | |||
*Metabolism: | |||
*Excretion: | |||
*Mechanism of Action: | |||
== | ==Comments== | ||
*Contains all coagulation factors and fibrinogen | |||
**40 mL/kg raises any factor by 100% (each unit is ~200mL) | |||
*May cause fluid overload | |||
*ABO compatibilty a must but crossmatch before transfusing not | |||
*INR of FFP is ~1.2 | |||
*Retains active coagulation factors for up to 5 days after being thawed | |||
==See Also== | ==See Also== | ||
*[[Transfusions]] | *[[Transfusions]] | ||
== | ==References== | ||
<references/> | |||
[[Category:Drugs]] | [[Category:Drugs]] | ||
[[Category:Heme/Onc]] | [[Category:Heme/Onc]] | ||
Revision as of 18:13, 29 May 2015
General
- Type: Blood products
- Dosage Forms:
- Common Trade Names:
Adult Dosing
- Transfuse at least 15 mL/kg at a time (4 units in 70-kg adult)
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Indications
- Rapid reversal of warfarin over-anticoagulation
- Bleeding and multiple coagulation defects
- Correction of coagulation defects for which no specific factor is available
- Transfusion of more than one blood volume w/ evidence of active bleeding + coagulopathy
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Comments
- Contains all coagulation factors and fibrinogen
- 40 mL/kg raises any factor by 100% (each unit is ~200mL)
- May cause fluid overload
- ABO compatibilty a must but crossmatch before transfusing not
- INR of FFP is ~1.2
- Retains active coagulation factors for up to 5 days after being thawed