Trazodone toxicity: Difference between revisions
m (Rossdonaldson1 moved page Trazodone Toxicity to Trazodone toxicity) |
No edit summary |
||
| Line 4: | Line 4: | ||
==Clinical Features== | ==Clinical Features== | ||
*CNS depression | |||
**Most common symptom | |||
**Rarely produces coma or seizures when it is the only drug ingested | |||
*Respiratory depresion | |||
**Fairly common (but only with coingestants) | |||
*Orthostatic hypotension | |||
*QT prolongation | |||
==Differential Diagnosis== | |||
==Diagnosis== | |||
==Treatment== | ==Treatment== | ||
*GI decontamination | |||
**[[Activated charcoal]] x1 | |||
**[[Gastric lavage]] (consider for coingestants) | |||
*[[QT prolongation]] | |||
**Treat [[torsades]] in usual manner | |||
*Hypotension | |||
**[[IVF]] | |||
**[[Norepinephrine]] | |||
***[[Dopamine]] is contraindicated | |||
==Disposition== | ==Disposition== | ||
*Consider discharge for | *Consider discharge for patients who remain asymptomatic for at least 6 hours | ||
==See Also== | |||
== | ==References== | ||
[[Category:Tox]] | [[Category:Tox]] | ||
Revision as of 09:46, 3 June 2015
Background
- Extremely safe in overdose as long as there are no coingestants
- Has serotonergic and alpha blocking effects
Clinical Features
- CNS depression
- Most common symptom
- Rarely produces coma or seizures when it is the only drug ingested
- Respiratory depresion
- Fairly common (but only with coingestants)
- Orthostatic hypotension
- QT prolongation
Differential Diagnosis
Diagnosis
Treatment
- GI decontamination
- Activated charcoal x1
- Gastric lavage (consider for coingestants)
- QT prolongation
- Treat torsades in usual manner
- Hypotension
- IVF
- Norepinephrine
- Dopamine is contraindicated
Disposition
- Consider discharge for patients who remain asymptomatic for at least 6 hours