Rho(D) immune globulin: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
*1st Trimester (through 12weeks) | |||
**--> give 50 microgm IM | |||
***(although there is no harm in giving the standard 300 microgram dose, which is more readily available) | |||
*2nd & 3rd Trimester | |||
**--> give 300 microgm IM once and send Kleihauer-Betke test | |||
**--> within 72hrs give additional 300 microgm/15 ml Rh-positive blood | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
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**Adult | **Adult | ||
**Pediatric | **Pediatric | ||
==Indications== | |||
*For fetal maternal hemorrhage | |||
*Risk = >4-12wks | |||
*Also given to Rh- male trauma patients who receive O+ blood to prevent future reaction with O+ transfusions<ref>Miraflor, E, et al. Emergency uncrossmatched transfusion effect on blood type alloantibodies. J Trauma. 2012; 72:48-53.</ref> | |||
==Contraindications== | ==Contraindications== | ||
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[[Category:Drugs]] | [[Category:Drugs]] | ||
[[Category:OB/GYN]] | [[Category:OB/GYN]] | ||
Revision as of 07:15, 29 August 2015
General
- Type:
- Dosage Forms:
- Routes of Administration:
- Common Trade Names:
Adult Dosing
- 1st Trimester (through 12weeks)
- --> give 50 microgm IM
- (although there is no harm in giving the standard 300 microgram dose, which is more readily available)
- --> give 50 microgm IM
- 2nd & 3rd Trimester
- --> give 300 microgm IM once and send Kleihauer-Betke test
- --> within 72hrs give additional 300 microgm/15 ml Rh-positive blood
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation risk:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Indications
- For fetal maternal hemorrhage
- Risk = >4-12wks
- Also given to Rh- male trauma patients who receive O+ blood to prevent future reaction with O+ transfusions[1]
Contraindications
- Allergy to class/drug
- Prior sensitization of mother
- Known Rh-negative father
- Known Rh-negative fetus (from cord blood)
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Comments
See Also
References
- ↑ Miraflor, E, et al. Emergency uncrossmatched transfusion effect on blood type alloantibodies. J Trauma. 2012; 72:48-53.