Esophageal perforation

Background

Causes

• Iatrogenic
• Boerhaave syndrome
• Thoracic Trauma
  • Penetrating
  • Blunt (rare)
• Caustic ingestion
• Foreign body
  • Bone, button battery
• Infection (rare)
• Tumor
• Aortic pathology
• Barrett esophagus
• Zollinger-Ellison syndrome

Clinical Features

• Mackler’s triad of chest pain, vomiting and subcutaneous emphysema is pathognomonic for the disease

History

• Pain
  • Acute, severe, unrelenting, diffuse
  • May be localized to chest, neck, abdomen; radiate to back and shoulders
• Dysphagia
• Dyspnea
• Hematemesis

Physical Exam

• Cervical subcutaenous emphysema
• Mediastinal emphysema
  • Takes time to develop
  • Absence does not rule out perforation

Differential Diagnosis

Chest pain

Critical

• Acute coronary syndromes (ACS)
  • STEMI
  • Non-STEMI
  • Unstable angina
• Aortic dissection
• Cardiac tamponade
• Coronary artery dissection
• Esophageal perforation (Boerhhaave's syndrome)
• Pulmonary embolism
• Tension pneumothorax

Emergent

• Cholecystitis
• Cocaine-associated chest pain
• Mediastinitis
• Myocardial rupture
• Myocarditis
• Pancreatitis
• Pericarditis
• Pneumothorax

Nonemergent

• Aortic stenosis
• Arthritis
• Asthma exacerbation
• Biliary colic
• Costochondritis
• Esophageal spasm
• Gastroesophageal reflux disease
• Herpes zoster / Postherpetic Neuralgia
• Hypertrophic cardiomyopathy
• Hyperventilation
• Mitral valve prolapse
• Panic attack
• Peptic ulcer disease
• Pleuritis
• Pneumomediastinum
• Pneumonia
• Rib fracture
• Stable angina
• Thoracic outlet syndrome
• Valvular heart disease
• Muscle sprain
• Psychologic / Somatic Chest Pain
• Spinal Root Compression
• Tumor

Thoracic Trauma

• Airway/Pulmonary
  • Bronchial injury
  • Diaphragmatic trauma
  • Hemothorax
  • Pneumomediastinum
  • Pulmonary contusion
  • Tracheal injury
  • Trachobronchial injury
  • Traumatic pneumothorax
    • Tension pneumothorax
• Cardiac/Vascular
  • Cardiac injury
    • Blunt cardiac injury
      • Cardiac contusion
      • Commotio cordis
    • Penetrating cardiac injury
    • Cardiac tamponade
  • Traumatic aortic transection
• Musculoskeletal
  • Clavicle fracture
    • Clavicle fracture (peds)
  • Rib fracture
    • Flail chest
  • Scapular fracture
  • Scapulothoracic dissociation
  • Sternoclavicular dislocation
  • Sternum fracture
  • Thoracic and lumbar fractures and dislocations
• Other
  • Esophageal injury or Perforation
  • Pneumomediastinum
  • Pneumopericardium
  • Traumatic asphyxia

Diagnosis

Imaging

• CXR
• CT chest
• Emergent endoscopy

Management

• Volume resuscitation
• Broad-spectrum IV antibiotics
• Emergent surgical consultation

See Also

• Esophageal Injury