Pemphigus vulgaris: Difference between revisions

Revision as of 03:15, 24 January 2016

Chronic autoimmune mucocutaneous disease against desmosomes in epidermis (bind keratinocytes)

Painful but rarely pruritic
Mucosal involvement common
- Presenting complaint in 50% of cases.
Primary lesions
- Tense and clear vesicles/bullae on head, trunk, mucosa.
- Become flaccid and turbid 2-3 days later
- Rupture and leave sensistive denuded area of skin
  - Slow to heal and prone to secondary infection.
Nikolsky's sign: Sliding pressure applied to normal skin adjacent to blister causes further ulceration.
- Intraepidermal acantholyis: Keratinocytes separated at the basal layer from one another.
- Gives appearance of lesion expanding into adjacent tissue.
- Transudate accumulate between keratinocyte and basement membrane which gives rise to new blisters.

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 ==Clinical Features==
+*Painful but rarely pruritic
+*Mucosal involvement common
+**Presenting complaint in 50% of cases.
+*Primary lesions
+**Tense and clear vesicles/bullae on head, trunk, mucosa.
+**Become flaccid and turbid 2-3 days later
+**Rupture and leave sensistive denuded area of skin
+***Slow to heal and prone to secondary infection.
+*Nikolsky's sign: Sliding pressure applied to normal skin adjacent to blister causes further ulceration.
+**Intraepidermal acantholyis: Keratinocytes separated at the basal layer from one another.
+**Gives appearance of lesion expanding into adjacent tissue.
+**Transudate accumulate between keratinocyte and basement membrane which gives rise to new blisters.
 ==Differential Diagnosis==