Loperamide

Administration

• Type:
• Dosage Forms:
• Routes of Administration:
• Common Trade Names: Imodium

Adult Dosing

• Acute Diarrhea:
  • 2 mg PO per dose
    • Start: 4 mg PO x1, then 2 mg PO after each loose stool; Max: 16 mg/day

• Chronic Diarrhea
  • 4-8 mg/day PO divided qd-tid
    • Start: 4 mg PO x1, then 2 mg PO after each loose stool until maint. dose established; Max: 16 mg/day

Pediatric Dosing

• Acute diarrhea:
  • 2-5 yo, 13-20 kg
    • Dose: 1 mg PO x1 after each loose stool
      • Max: 3 mg/day
      • Use OTC 1 mg/5 sol or 1 mg/7.5 mL susp
  • 6-8 yo, 20-30 kg
    • Dose: start 2 mg PO x1, then 1 mg PO after each loose stool
      • Max: 4 mg/day
  • 8-11 yo, 30-40 kg
    • Dose: start 2 mg PO x1, then 1 mg PO after each loose stool
      • Max: 6 mg/day
  • 12 yo and older
    • Dose: start 4 mg PO x1, then 2 mg PO after each loose stool
      • Max: 8 mg/day
• Chronic diarrhea
  • 0.08-0.24 mg/kg/day PO divided bid-tid
    • Max: 2 mg/dose

Special Populations

• Pregnancy Rating:
• Lactation risk:

Renal Dosing

• Adult:
• Pediatric:

Hepatic Dosing

• Adult:
• Pediatric:

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life:
• Metabolism:
• Excretion: