Lymphoma: Difference between revisions
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==Hodgkin Lymphoma== | == Hodgkin Lymphoma == | ||
===Diagnosis=== | === Background === | ||
*Painless, firm, lymph node (usually cervical or supraclavicular) | |||
*Spreads from source lymph node to adjacent nodes | |||
*Bimodal distribution: young adulthood and older aged | |||
*Most common malignancy between ages of 15-19 yo | |||
*Survival >90% in low-risk pts | |||
=== Diagnosis === | |||
*Painless, firm, lymph node (usually cervical or supraclavicular) | |||
*"B" symptoms: fever, night sweats, wt loss | *"B" symptoms: fever, night sweats, wt loss | ||
===Work-Up=== | === Work-Up === | ||
*CXR | |||
*CT neck/C/A/P | *CXR | ||
*CT neck/C/A/P | |||
*LN biopsy | *LN biopsy | ||
===DDx=== | === DDx === | ||
Cervical lymphadenopathy | |||
#Non-Hodgkin lymphoma | Cervical lymphadenopathy | ||
#Mononucleosis | |||
#Toxoplasmosis | #Non-Hodgkin lymphoma | ||
#Branchial cleft lesions | #Mononucleosis | ||
#Cat scratch disease | #Toxoplasmosis | ||
#Branchial cleft lesions | |||
#Cat scratch disease | |||
#Mycobacterial adenitis | #Mycobacterial adenitis | ||
===Treatment=== | === Treatment === | ||
*Manage acute complications | |||
**Superior vena cava syndrome | *Manage acute complications | ||
**Upper airway compression | **Superior vena cava syndrome | ||
**Upper airway compression | |||
***Do NOT give steroids | ***Do NOT give steroids | ||
==Non-Hodgkin Lymphoma== | == Non-Hodgkin Lymphoma == | ||
===Background=== | |||
*May originate in lymphatic system or any organ in the body | === Background === | ||
*Occurs in children | |||
*Risk factors | *May originate in lymphatic system or any organ in the body | ||
*Occurs in children >5yr old | |||
*Risk factors | |||
**Immunosuppression (HIV, Crohn, chemo recipients) | **Immunosuppression (HIV, Crohn, chemo recipients) | ||
===Diagnosis=== | === Diagnosis === | ||
*Lymphadenopathy | |||
*Hepatosplenomegaly | *Lymphadenopathy | ||
*"B" symptoms | *Hepatosplenomegaly | ||
*GI | *"B" symptoms | ||
*GI | |||
**Bleeding, intussusception, N/V | **Bleeding, intussusception, N/V | ||
===Work-Up=== | === Work-Up === | ||
*CBC | |||
*Chemistry | *CBC | ||
*Uric acid | *Chemistry | ||
*LFT | *Uric acid | ||
*LFT | |||
*CXR | *CXR | ||
===Complications=== | === Complications === | ||
*Superior vena cava syndrome | |||
*Pleural/pericardial effusions | *Superior vena cava syndrome | ||
*Pleural/pericardial effusions | |||
*Spinal cord compression | *Spinal cord compression | ||
==Source== | == Source == | ||
Tintinalli | |||
Tintinalli | |||
== See Also == | |||
[[Acute Leukemia]] | |||
[[Category:Heme/Onc]] | [[Category:Heme/Onc]] | ||
Revision as of 02:46, 6 August 2011
Hodgkin Lymphoma
Background
- Spreads from source lymph node to adjacent nodes
- Bimodal distribution: young adulthood and older aged
- Most common malignancy between ages of 15-19 yo
- Survival >90% in low-risk pts
Diagnosis
- Painless, firm, lymph node (usually cervical or supraclavicular)
- "B" symptoms: fever, night sweats, wt loss
Work-Up
- CXR
- CT neck/C/A/P
- LN biopsy
DDx
Cervical lymphadenopathy
- Non-Hodgkin lymphoma
- Mononucleosis
- Toxoplasmosis
- Branchial cleft lesions
- Cat scratch disease
- Mycobacterial adenitis
Treatment
- Manage acute complications
- Superior vena cava syndrome
- Upper airway compression
- Do NOT give steroids
Non-Hodgkin Lymphoma
Background
- May originate in lymphatic system or any organ in the body
- Occurs in children >5yr old
- Risk factors
- Immunosuppression (HIV, Crohn, chemo recipients)
Diagnosis
- Lymphadenopathy
- Hepatosplenomegaly
- "B" symptoms
- GI
- Bleeding, intussusception, N/V
Work-Up
- CBC
- Chemistry
- Uric acid
- LFT
- CXR
Complications
- Superior vena cava syndrome
- Pleural/pericardial effusions
- Spinal cord compression
Source
Tintinalli