Anticoagulant reversal for life-threatening bleeds: Difference between revisions

Revision as of 07:12, 25 March 2016

Anticoagulant	Half-life	Removed by HD	Strategies to reverse or minimize anticoagulant effects
Apixaban (Eliquis®)	8-15 hrs (longer in renal impairment)	No	If ingested within 2 hours, administer activated charcoal 4-factor PCC (Kcentra™)^ 25units/kg—max 2500 units for treatment of documented intracranial hemorrhage 50 units/kg—max 5000 units for all other life-threatening bleeds
Edoxaban (Savaysa®)	10-14 hrs (longer in renal impairment)	~ 25%	As above
Rivaroxaban (Xarelto®)	9-13 hrs (longer in renal impairment)	No	As above
Fondaparinux (Arixtra®)	17-21 hrs (significantly longer in renal impairment)	No	4-factor PCC (Kcentra™)^ 50 units/kg—max 5000 units

Anticoagulants	Half-life	Removed by HD	Strategies to reverse or minimize anticoagulant effects
Argatroban	40-50 min	~ 20%	Turn off infusion
Bivalirudin (Angiomax®)	25 min (up to 1 hr in severe renal impairment)	~ 25%	As above
Dabigatran (Pradaxa®)	14-17 hrs (up to 34 hrs in severe renal impairment)	~ 65%	If ingested within 2 hours, administer activated charcoal Idarucizumab (Praxbind®) 5g IV For end stage renal disease patient with pre-existing vascular access, consult nephrology to consider dialysis.

Anticoagulants	Half-life	Removed by HD	Strategies to reverse or minimize anticoagulant effects
Dalteparin (Fragmin®)	3-5 hrs (longer in renal impairment)	~ 20%	Use protamine for partial neutralization (~60%) Protamine IV: < 8 hours since last dose: Protamine 50 mg 8-12 hours since last dose: Protamine 25 mg >12 hours since last dose: Unlikely useful unless CrCl < 30 mL/min (or 25mg fixed dose) Dose of protamine for each 100 units dalteparin or 1mg of enoxaparin administered Obtain baseline anti-Xa activity level Monitor anti-Xa activity level to confirm reversal
Enoxaparin (Lovenox®)			As above
Heparin	30-90 min (dose dependent)	Partial	Turn off infusion Protamine 50 mg IV

^Off-label

Authors:

@@ Line 43: / Line 43: @@
 | align="center" style="background:#f0f0f0;"|'''Strategies to reverse or minimize anticoagulant effects'''
 |-
-| Dalteparin (Fragmin®)||3-5 hrs (longer in renal impairment)||~ 20%||
+| [[Dalteparin]] (Fragmin®)||3-5 hrs (longer in renal impairment)||~ 20%||
 *Use protamine for partial neutralization (~60%)
-*Protamine IV:
+*[[Protamine]] IV:
-**< 8 hours since last LMWH dose: Protamine 50 mg
+**< 8 hours since last dose: [[Protamine]] 50 mg
-**8-12 hours since last LMWH dose: Protamine 25 mg
+**8-12 hours since last dose: [[Protamine]] 25 mg
-**>12 hours since last LMWH dose: Unlikely useful unless CrCl < 30 mL/min (or 25mg fixed dose)
+**>12 hours since last dose: Unlikely useful unless CrCl < 30 mL/min (or 25mg fixed dose)
 *Dose of protamine for each 100 units dalteparin or 1mg of enoxaparin administered
 *Obtain baseline anti-Xa activity level
 *Monitor anti-Xa activity level to confirm reversal
 |-
-| Enoxaparin (Lovenox®)||||||As above
+| [[Enoxaparin]] (Lovenox®)||||||As above
 |-
-| Heparin||30-90 min (dose dependent)||Partial||
+| [[Hepari]]n||30-90 min (dose dependent)||Partial||
 *Turn off infusion
-*Protamine 50 mg IV
+*[[Protamine]] 50 mg IV
 |}