Amphetamines: Difference between revisions

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==Background==
==Background==
*Unlike cocaine, duration of action may be 12hr or longer
- Time- oral- 30min, inhaled instant
- Time- oral- 30min, inhaled instant


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- hallucinogenic amphet deriv may not show up on tox screen AKA Entactogens- enabling user to touch within
- hallucinogenic amphet deriv may not show up on tox screen AKA Entactogens- enabling user to touch within


===Meth Amphet===
===Methamphetamine===
- more combative- delusions of parasites- formication\ self mutilate
*More combative
 
*Delusions of parasites, formication, self-mutilate
- more dysphoric
*more dysphoric
 
- AKA ice crystal speed go crank


===MDMA Ecstacy===
===MDMA Ecstacy===
- changes 5HT neuroxmitter
*Increases serotonin, dopamine
 
*Lasts 3 - 5hrs
- inc dopamine
*Hyponatremia
 
*
- lasts 3 - 5hrs
 
- usual dose for psychgTx- 50 - 200mg
 
- cardiac effects
 
- euphoria- interpersonal clgseness- introspection
 
- enhanced socialibility (rave)
 
- deep empathy
 
- severe withdrawal with anxiety and depression
 
- tolerance developes to positve and neg effects with inc use
 
===Theraputic Uses===
# appetite suppression
# inc alertness
# narcolepsy
# adhd
# inc mood
# avoid boredom on repetitive task jobs
 


==Diagnosis==
==Diagnosis==
===Alpha===
===Alpha===
- pupils dilate
*pupils dilate
 
*sweat
- sweat
*decrease gi peristalsis
 
*constrict blood vessels
- decrease gi peristalsis
 
- constrict blood vessels


===Beta===
===Beta===
- inc HR and contractility
*inc HR and contractility
 
*dilate bronchi
- dilate bronchi
*dilate muscle beds
 
- dilate muscle beds


===Mixed===
===Mixed===
- delusions, paranoia, aggression, poor judgement, hallucinate, confusion
*delusions, paranoia, aggression, poor judgement, hallucinate, confusion


==Treatment==
==Treatment==
Benzos
*Benzos


==See Also==
==See Also==

Revision as of 03:28, 5 January 2012

Background

  • Unlike cocaine, duration of action may be 12hr or longer

- Time- oral- 30min, inhaled instant

- hepatic and renal excretion- lasts 6- 24 hrs

- if tolerance developes- physical exam may yield normal findings

- desipramine and amantadine can give false positive for urine amphet test

- hallucinogenic amphet deriv may not show up on tox screen AKA Entactogens- enabling user to touch within

Methamphetamine

  • More combative
  • Delusions of parasites, formication, self-mutilate
  • more dysphoric

MDMA Ecstacy

  • Increases serotonin, dopamine
  • Lasts 3 - 5hrs
  • Hyponatremia

Diagnosis

Alpha

  • pupils dilate
  • sweat
  • decrease gi peristalsis
  • constrict blood vessels

Beta

  • inc HR and contractility
  • dilate bronchi
  • dilate muscle beds

Mixed

  • delusions, paranoia, aggression, poor judgement, hallucinate, confusion

Treatment

  • Benzos

See Also

Toxidromes

Source

MISTRY 6/06