Lactic acidosis: Difference between revisions
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*Most common cause of metabolic acidosis in hospitalized patients | *Most common cause of metabolic acidosis in hospitalized patients | ||
==Clinical | ==Clinical Features== | ||
*Anorexia | *Anorexia | ||
*Nausea | *[[Nausea]] | ||
*Vomiting | *[[Vomiting]] | ||
*Abdominal pain | *[[Abdominal pain]] | ||
*Lethargy | *Lethargy | ||
*Hyperventilation | *[[Hyperventilation]] | ||
*Hypotension | *[[Hypotension]] | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
Revision as of 02:35, 15 June 2016
Background
- Most common cause of metabolic acidosis in hospitalized patients
Clinical Features
- Anorexia
- Nausea
- Vomiting
- Abdominal pain
- Lethargy
- Hyperventilation
- Hypotension
Differential Diagnosis
Lactic acidosis
By Type
- Type A (tissue hypoperfusion)
- Type B (decreased utilization)
- Alcoholism
- ↓ Lactate utilization secondary to hepatic dysfunction
- ↓ NAD+/NADH ratio leads to ↑ conversion of pyruvate to lactate
- Metformin
- DKA
- Mainly due to D-lactate production, though hypovolemia contributes
- Liver disease (decreased clearance)
- Adrenergic receptor agonism; viz., albuterol, epinephrine, etc
- Malignancy
- Carbon Monoxide poisoning
- Cyanide poisoning
- Alcoholism
- Type D
- episodes of encephalopathy and metabolic acidosis typically following high carbohydrate meals in patients with short bowel syndrome
- metabolic acidosis and high serum anion gap, normal lactate level, short bowel syn or other forms of malabsorption, and characteristic neurologic findings
- Type D lactate is not detected with standard lactate levels
Complete List
- Any shock state
- SIRS; lactate may be 2-5 mEq/L
- Thiamine deficiency; more often seen in ICU settings; Thiamine is a co-factor for pyruvate dehydrogenase
- Seizure
- Dead gut
- Hepatic failure
- Malignancy
- Exercise
- Albuterol and other beta agonists[1][2]
- Toxicologic Causes:
- Cyanide
- Carbon Monoxide
- Metformin
- Didanosine
- Stavudine
- Zidovudine
- Linezolid
- Strychnine
- Emtriva
- Rotenone (Fish Poison
- NaAzide (Lab Workers)
- APAP (if Liver Fx)
- Phospine (rodenticide)
- NaMonofluoroacetate (Coyote Poison‐ give Etoh as antidote)
- INH (if patient seizes)
- Hemlock
- Valproate
- Hydrogen Sulfide
- Nitroprusside (if cyanide toxic)
- Ricin & Castor Beans
- Propofol
- Sympathomimetics (cocaine, methamphetamine)
- Jequirty peas (Abrus precatorius)
- Prunus Amygdalus plants
- Crab tree apple seeds & cassava (yucca)
- HAART-induced lactic acidosis
Diagnosis
- Hyperlactatemia = Lactate >2 mEq/L
- Lactic Acidosis = Lactate >4 mEq/L
Lactate False Positives=
- Beta-agonists or beta stimulation
- Extreme exercise
- Seizures, immediate ictal period
- Hepatic failure
- Lactate ringer's solution unlikely to cause false positive except in hepatic failure
Management
- Treat underlying cause
Disposition
- Depends on underlying cause