Chlordiazepoxide: Difference between revisions

(Text replacement - "Category:Drugs" to "Category:Pharmacology")
(Text replacement - "==Sources==" to "==References==")
Line 46: Line 46:
*[[EBQ:Outpatient use of benzodiazepines for the treatment of acute alcohol withdrawal]]
*[[EBQ:Outpatient use of benzodiazepines for the treatment of acute alcohol withdrawal]]


==Sources==
==References==
Lexicomp, UpToDate
Lexicomp, UpToDate
<references/>
<references/>
[[Category:Pharmacology]]
[[Category:Pharmacology]]

Revision as of 08:26, 27 June 2016

General

  • Type: Benzodiazepines
  • Dosage Forms: 5,10, 25 mg tab
  • Common Trade Names: Librium

Adult Dosing

  • EtOH withdrawal
    • Example taper:
      • Day 1: 50 mg q6h
      • Day 2: 25 mg q6h
      • Day 3: 25 mg q12h
      • Day 4: 25 mg at night
    • Max 300 mg per 24 hours

Pediatric Dosing

  • N/A

Special Populations

  • Pregnancy Rating: Category D
  • Lactation risk categories: L4; enters breast milk, not recommended
  • Renal Dosing: CrCl < 10 cc/min : 1/2 normal dose
  • Hepatic Dosing: No specific guidelines. Use caution as hepatically metabolized

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • CNS depression
  • Paradoxical agitation
  • Drug induced EPS
  • Bone marrow suppression, agranulocytosis

Common

  • Drowsiness

Pharmacology

  • Time to peak: 0.5-2 h
  • Half-life: Parent compound 6-28 h, demoxepam (metabolite) 14-95 h
  • Metabolism: Hepatic to desmethyldiazepam (active), desmethylchlordiazepoxide, demoxepam
  • Excretion: Urine
  • Mechanism of Action: Benzodiazepines

See Also

References

Lexicomp, UpToDate

Retrieved from "https://www.wikem.org/w/index.php?title=Chlordiazepoxide&oldid=78380"