P450: Difference between revisions
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==Antimicrobials== | ==Antimicrobials== | ||
===Avoid / P450 Inhibitors=== | ===Avoid / P450 Inhibitors=== | ||
*[[Quinolones]], | *[[Quinolones]], especially [[levofloxacin]] | ||
*[[Macrolides]], | *[[Macrolides]], especially [[erythromycin]] | ||
*[[Bactrim]] and sulfonamides | *[[Bactrim]] and sulfonamides | ||
*[[Flagyl]] | *[[Flagyl]] | ||
Revision as of 14:10, 30 July 2016
Background
Antimicrobials
Avoid / P450 Inhibitors
- Quinolones, especially levofloxacin
- Macrolides, especially erythromycin
- Bactrim and sulfonamides
- Flagyl
- Nafcillin, oxacillin
Use
- Azithromycin
- [[Gentamicin
- Cephalosporin, aminopenicillins
- Nitrofurantoin
- Clindamycin
- Vancomycin
Significant P450 Inhibitors in General
- Grapefruit juice
- Valproate
- INH
- Protease inhibitors (-navir, i.e. ritonavir)
- SSRIs, except escitalopram
- Amiodarone
- Fluoroquinolones
- Sulfonamides
- Macrolides
- Cimetidine
- Omeprazole
- Ketoconazole
- Acute EtOH
Significant P450 Inducers in General
- Phenytoin
- Carbamazepine
- Ethosuximide
- Quinidine/quinine
- Rifampin
- Griseofulvin
- Glucocorticoids
- Barbituates
- St. John's wort
- Chronic EtOH
- Tobacco smoking