Acute lymphocytic leukemia: Difference between revisions
Neil.m.young (talk | contribs) (Text replacement - "==Diagnosis==" to "==Evaluation==") |
Neil.m.young (talk | contribs) (Text replacement - " ==" to "==") |
||
| Line 1: | Line 1: | ||
==Background == | ==Background== | ||
*Characterized by proliferation of immature lymphoblast( >20% in periphery) | *Characterized by proliferation of immature lymphoblast( >20% in periphery) | ||
*Less than 20% of acute leukemias in adults, | *Less than 20% of acute leukemias in adults, | ||
| Line 20: | Line 20: | ||
*Get extra purple top for flow cytometry, especially before transfusion | *Get extra purple top for flow cytometry, especially before transfusion | ||
==Treatment == | ==Treatment== | ||
*Aggressive IV hydration | *Aggressive IV hydration | ||
*If febrile, complete cultures and broad spectrum antibiotics | *If febrile, complete cultures and broad spectrum antibiotics | ||
| Line 28: | Line 28: | ||
**see [[Tumor Lysis Syndrome]] | **see [[Tumor Lysis Syndrome]] | ||
==See Also == | ==See Also== | ||
*[[Oncologic emergencies]] | *[[Oncologic emergencies]] | ||
*[[Acute leukemia]] | *[[Acute leukemia]] | ||
Revision as of 19:13, 3 August 2016
Background
- Characterized by proliferation of immature lymphoblast( >20% in periphery)
- Less than 20% of acute leukemias in adults,
- Most common form in children (see also Leukemia (Peds))
- Highest incidence in 7th decade of life
Clinical Features
- Lymphocytosis, neutropenia, anemia, thrombocytopenia,
- Lymphadenopathy, hepatosplenomegaly
- CNS and testes involvement common
Differential Diagnosis
Acute Leukemia/Lymphoma
Evaluation
- CXR
- CBC with peripheral smear
- Chem7, ca, mg, phos, Uric Acid, UA, LDH (to check for Tumor Lysis)
- LFTs, Coags, FDP, D-Dimer, Haptoglobin, Fibrinogen (to check for DIC)
- Get extra purple top for flow cytometry, especially before transfusion
Treatment
- Aggressive IV hydration
- If febrile, complete cultures and broad spectrum antibiotics
- Manage Complications
- see DIC
- see Leukostasis
- see Tumor Lysis Syndrome