Caspofungin: Difference between revisions
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==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*Erythema multiforme, Stevens-Johnson syndrome | *[[Erythema multiforme]], [[Stevens-Johnson syndrome]] | ||
*Pancreatitis, hepatic failure | *[[Pancreatitis]], [[hepatic failure]] | ||
*Sepsis | *[[Sepsis]] | ||
*Nephrotoxicity | *[[Nephrotoxicity]] | ||
*Pleural effusion, respiratory distress | *[[Pleural effusion]], respiratory distress | ||
*Angioedema | *[[Angioedema]] | ||
===Common=== | ===Common=== | ||
*Hypotension | *[[Hypotension]] | ||
*Rash | *[[Rash]] | ||
*Diarrhea | *[[Diarrhea]] | ||
*Histaminergic reaction (flushing, warmth, pruritus) | *[[Histaminergic reaction]] (flushing, warmth, pruritus) | ||
*Transaminitis | *[[Transaminitis]] | ||
*Fever | *[[Fever]] | ||
==Pharmacology== | ==Pharmacology== | ||
Revision as of 06:15, 8 September 2016
Administration
- Type: Antifungal, particularly used for aspergillosis and candidiasis
- Dosage Forms:
- Routes of Administration: IV
- Common Trade Names:
Adult Dosing
- 50-150 mg IV daily
Pediatric Dosing
3 months or older
- 50-70 mg/m(2) daily
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
Renal Dosing
- Adult:
- Pediatric:
Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Erythema multiforme, Stevens-Johnson syndrome
- Pancreatitis, hepatic failure
- Sepsis
- Nephrotoxicity
- Pleural effusion, respiratory distress
- Angioedema
Common
- Hypotension
- Rash
- Diarrhea
- Histaminergic reaction (flushing, warmth, pruritus)
- Transaminitis
- Fever
Pharmacology
- Half-life: 13-15 hours
- Metabolism: spontaneous degradation, hydrolysis and N-acetylation
- Excretion: Fecal, renal
Mechanism of Action
- Inhibits beta (1,3)-D-glucan synthesis in fungal cell wall