Torsemide: Difference between revisions
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==General== | |||
*80-100% oral bioavailability as opposed to [[furosemide]]<ref>Asare K. Management of Loop Diuretic Resistance in the Intensive Care Unit. Am J Health Syst Pharm. 2009;66(18):1635-1640.</ref> | |||
==Administration== | ==Administration== | ||
*Type: Loop diuretic | *Type: Loop [[diuretic]] | ||
*Dosage Forms: | *Dosage Forms: | ||
*Routes of Administration: IV, PO | *Routes of Administration: IV, PO | ||
| Line 6: | Line 9: | ||
==Adult Dosing== | ==Adult Dosing== | ||
''40mg [[furosemide]] = 20mg torsemide = 1mg [[bumetanide]]'' | ''40mg [[furosemide]] = 20mg torsemide = 1mg [[bumetanide]] = 50mg [[Ethacrynic acid]]'' | ||
*5-200 mg PO or IV daily. Titrate to effect by doubling dose | *5-200 mg PO or IV daily. Titrate to effect by doubling dose | ||
| Line 33: | Line 36: | ||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: 2-4 hours | *Half-life: 2-4 hours | ||
*Metabolism: P450 | *Metabolism:[[P450]] | ||
*Excretion: Renal | *Excretion: Renal | ||
Latest revision as of 21:03, 15 January 2017
General
- 80-100% oral bioavailability as opposed to furosemide[1]
Administration
- Type: Loop diuretic
- Dosage Forms:
- Routes of Administration: IV, PO
- Common Trade Names: Demadex
Adult Dosing
40mg furosemide = 20mg torsemide = 1mg bumetanide = 50mg Ethacrynic acid
- 5-200 mg PO or IV daily. Titrate to effect by doubling dose
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: B
- Lactation risk: Infant risk cannot be ruled out
Renal dosing: no adjustment Hepatic dosing: no adjustment
Contraindications
- Allergy to class/drug
- Anuria
Adverse Reactions
Serious
- Ventricular tachycardia
- SJS/TEN
- Ototoxicity
Common
- Polyuria
- Rhinitis
Pharmacology
- Half-life: 2-4 hours
- Metabolism:P450
- Excretion: Renal
Mechanism of Action
- Loop diuretic: interferes with Na/K/Cl cotransport system, inhibiting reabsorption of Na/Cl in the ascending limb of the loop of Henle
Comments
See Also
References
- ↑ Asare K. Management of Loop Diuretic Resistance in the Intensive Care Unit. Am J Health Syst Pharm. 2009;66(18):1635-1640.