Hepatocellular carcinoma: Difference between revisions

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==Background==
==Background==
*most common form of liver cancer
==Clinical Features==
*Risk factors include:
**[[Hepatitis]] B or C
**toxins (alcohol or aflatoxin)
**Metabolic conditions ([[hemochromatosis]], [[alpha 1-antitrypsin deficiency]], [[non-alcoholic fatty liver disease]])


==Differential Diagnosis==
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*Cirrhosis
{{Hemorrhoid background}}
*[[Hepatitis]]
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*[[Budd-Chiari syndrome]]
 
==Evaluation==
 
*LFT, CBC, BMP, GGT
 
*Ultrasound
==Types==
*Initial CT and MRI nonemergently
 
*Biopsy
[[File:M 44 anus 22.jpg|thumb|[[Special:MyLanguage/External hemorrhoid|External hemorrhoid]]]]
*Surveillance with alfa-fetoprotein (AFP) in combination with US<ref>Bialecki ES and Di Bisceglie AM. Diagnosis of hepatocellular carcinoma. HPB (Oxford). 2005; 7(1): 26–34.</ref>
[[File:Perianal thrombosis 01.jpg|thumb|Thrombosed [[Special:MyLanguage/external hemorrhoid|external hemorrhoid]]]]
*[[Special:MyLanguage/Internal hemorrhoid|Internal hemorrhoid]]
**Originate above the dentate line
**Painless
*[[Special:MyLanguage/External hemorrhoid|External hemorrhoid]]
**Originate below the dentate line
**Painful
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{{Internal Hemorrhoid Chart}}
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==Treatment==
 
*Increase fiber
*Sitz baths
*Topical steroid - Hydrocortizone
*Topical anti-spasmodic - Nifedipine
*See also treatment by specific type:
**[[Special:MyLanguage/Internal hemorrhoid|Internal hemorrhoid]]
**[[Special:MyLanguage/External hemorrhoid|External hemorrhoid]]


==Management==
*Supportive, symptomatic treatment


==Disposition==


==See Also==
==See Also==


==External Links==
*[[Special:MyLanguage/Anorectal disorders|Anorectal disorders]]
 
 


==References==
==References==
<references/>
<references/>


[[Category:GI]]
[[Category:GI]]
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Latest revision as of 23:02, 4 January 2026


Background

Anatomy of the anus.
Internal and external hemorrhoids divided by pectinate (dentate) line
  • Pathologic state cccurs when internal or external hemorrhoid plexus become engorged, prolapsed, or thrombosed
  • Bleeding is usually limited (surface of stool, on toilet tissue, at end of defecation)
    • Passage of blood clots requires evaluation for colon lesions

Risk Factors


Types

Internal hemorrhoid chart

Internal hemorrhoid grades
Grade Description Diagram Picture
I
  • Luminal protrusion above dentate line
  • No prolapse
  • Painless bleeding
Piles Grade 1.svg Endoscopic view
II
  • Prolapse with spontaneous reduction
  • Prolapse during straining
Piles Grade 2.svg Hemrrhoids 04.jpg
III
  • Prolapse requires manual reduction
  • Prolapse during straining
Piles Grade 3.svg Hemrrhoids 05.jpg
IV
  • Prolapse—nonreducible
  • Can result in edema and strangulation
Piles Grade 4.svg Piles 4th deg 01.jpg


Treatment


See Also


References